Synthesis and Surface Modification of Highly Monodispersed, Spherical Gold Nanoparticles of 50-200 nm

被引:524
作者
Perrault, Steven D. [1 ]
Chan, Warren C. W. [1 ]
机构
[1] Univ Toronto, Terrence Donnelly Ctr Cellular & Biomol Res, Inst Biomat & Biomed Engn, Toronto, ON M5S 3E1, Canada
关键词
PARTICLE-SIZE; NUCLEATION; CLUSTERS; SHAPE;
D O I
10.1021/ja907069u
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Elucidating the impact of nanoparticle size and shape on biological systems is of fundamental importance to nanotoxicology and biomedicine. Currently, the ability to determine this is limited by the lack of a model nanoparticle system having a narrow size and shape distribution over the relevant size range (2-200 nm). Hydroquinone can be used to produce 50-200 nm gold nanoparticles that are relatively monodispersed in size with nearly spherical shapes.
引用
收藏
页码:17042 / +
页数:4
相关论文
共 13 条
[1]   Seeding of colloidal Au nanoparticle solutions. 2. Improved control of particle size and shape [J].
Brown, KR ;
Walter, DG ;
Natan, MJ .
CHEMISTRY OF MATERIALS, 2000, 12 (02) :306-313
[2]   Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells [J].
Chithrani, BD ;
Ghazani, AA ;
Chan, WCW .
NANO LETTERS, 2006, 6 (04) :662-668
[3]   In vivo tumor targeting of tumor necrosis factor-α-loaded stealth nanoparticles:: Effect of MePEG molecular weight and particle size [J].
Fang, C ;
Shi, B ;
Pei, YY ;
Hong, MH ;
Wu, J ;
Chen, HZ .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2006, 27 (01) :27-36
[4]   CONTROLLED NUCLEATION FOR REGULATION OF PARTICLE-SIZE IN MONODISPERSE GOLD SUSPENSIONS [J].
FRENS, G .
NATURE-PHYSICAL SCIENCE, 1973, 241 (105) :20-22
[5]   Radiation-induced and chemical formation of gold clusters [J].
Gachard, E ;
Remita, H ;
Khatouri, J ;
Keita, B ;
Nadjo, L ;
Belloni, J .
NEW JOURNAL OF CHEMISTRY, 1998, 22 (11) :1257-1265
[6]   Controlled Particle Growth of Silver Sols through the Use of Hydroquinone as a Selective Reducing Agent [J].
Gentry, Stuart T. ;
Fredericks, Stephen J. ;
Krchnavek, Robert .
LANGMUIR, 2009, 25 (05) :2613-2621
[7]   Evidence for seed-mediated nucleation in the chemical reduction of gold salts to gold nanoparticles [J].
Jana, NR ;
Gearheart, L ;
Murphy, CJ .
CHEMISTRY OF MATERIALS, 2001, 13 (07) :2313-2322
[8]   Nanoparticle-mediated cellular response is size-dependent [J].
Jiang, Wen ;
Kim, Betty Y. S. ;
Rutka, James T. ;
Chan, Warren C. W. .
NATURE NANOTECHNOLOGY, 2008, 3 (03) :145-150
[9]   LONG-LIVED NONMETALLIC SILVER CLUSTERS IN AQUEOUS-SOLUTION - PREPARATION AND PHOTOLYSIS [J].
LINNERT, T ;
MULVANEY, P ;
HENGLEIN, A ;
WELLER, H .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (12) :4657-4664
[10]   Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts [J].
Lundqvist, Martin ;
Stigler, Johannes ;
Elia, Giuliano ;
Lynch, Iseult ;
Cedervall, Tommy ;
Dawson, Kenneth A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (38) :14265-14270