NMR imaging study of cross-linked high-amylose starch tablets - The effect of drug loading

NMR imaging techniques were used to study the effect of drug loading in cross-linked high-amylose starch tablets. The tablets contained acetaminophen with loading levels from 10 to 40 wt%. The absolute amount of the drug released increased with a larger amount of drug loading, but the percentages of drug released had only minor differences for the different tablets, probably due to the rapid formation of a gel layer for all the tablets, which slowed down drug release significantly. The release of drugs from the tablets in all cases is dominated by a diffusion mechanism before the disappearance of the dry core of the tablets. Radial and axial swelling and water uptake were found to increase with the amount of drug loading. The diffusion rates of water were comparable at the initial stage for all the tablets with different loadings, but became faster later for the tablets with higher amounts of drug loading as water diffusion may be facilitated by the hydrophilicity of the drug.