Covalent histone modifications - miswritten, misinterpreted and mis-erased in human cancers

被引：850

作者：

Chi, Ping ^{[1
,2
]}

Allis, C. David ^{[1
]}

Wang, Gang Greg ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Chromatin Biol & Epigenet, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 07期

基金：

美国国家卫生研究院;

关键词：

MIXED-LINEAGE LEUKEMIA; PROMOTES NEOPLASTIC TRANSFORMATION; DEMETHYLASE JMJD3 CONTRIBUTES; PARTIAL TANDEM DUPLICATION; PHD FINGER; TUMOR-SUPPRESSOR; BREAST-CANCER; CELL-PROLIFERATION; PROSTATE-CANCER; TRANSCRIPTIONAL REPRESSION;

D O I：

10.1038/nrc2876

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Post-translational modification of histones provides an important regulatory platform for processes such as gene transcription and DNA damage repair. It has become increasingly apparent that the misregulation of histone modification, which is caused by the deregulation of factors that mediate the modification installation, removal and/or interpretation, actively contributes to human cancer. In this Review, we summarize recent advances in understanding the interpretation of certain histone methylations by plant homeodomain finger-containing proteins, and how misreading, miswriting and mis-erasing of histone methylation marks can be associated with oncogenesis and progression. These observations provide us with a greater mechanistic understanding of epigenetic alterations in human cancers and might also help direct new therapeutic interventions in the future.

引用

页码：457 / 469

页数：13

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