SELDI-TOF mass spectra: A view on sources of variation

被引：38

作者：

Dijkstra, Martijn

Vonk, Roel J.

Jansen, Ritsert C.

机构：

[1] Univ Groningen, Bioinformat Ctr, Biomol Sci & Biotechnol Inst, NL-9700 AV Groningen, Netherlands

[2] Univ Med Ctr Groningen, Ctr Med Biom, NL-9713 AV Groningen, Netherlands

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2007年 / 847卷 / 01期

关键词：

mass spectrometry; quantitative analysis; SELDI; mixture models; spectrum analysis;

D O I：

10.1016/j.jchromb.2006.11.004

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Adequate interpretation of mass spectrometry data can yield valuable biomarkers. However, spectrum interpretation is a complicated task. This paper reviews the various factors that determine a sample's spectrum and demonstrates the role of these factors in the interpretation process. We derive a simulation model that adequately predicts the expected spectrum based on known sample content and, in the reverse mode, obtain an analysis model that adequately fits an observed spectrum based on the hypothesized sources of variation. (c) 2006 Elsevier B.V All rights reserved.

引用

页码：12 / 23

页数：12

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