Highly cytotoxic benzo[c]pyrido[2,3,4-kl]acridines

被引：7

作者：

Chackal, S

Facompré, M

Houssin, R

Goossens, JF

Pommery, N

Hénichart, JP

Bailly, C

机构：

[1] INSERM, U524, F-59045 Lille, France

[2] IRCL, Lab Pharmacol Antitumorale, Ctr Oscar Lambret, F-59045 Lille, France

[3] Univ Lille 2, Inst Chim Pharmaceut Albert Lespagnol, EA 2692, F-59006 Lille, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(02)01066-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Several benzo[c]pyrido[2,3,4-kl]acridines bearing different substituents on the A and E rings were synthesized and evaluated for their capacity to bind to DNA and to inhibit DNA topoisomerases. Potent cytotoxic compounds were discovered but no strict correlation with their DNA binding affinity and effects on topoisomerases were observed. DNA is one but not the unique target of these compounds. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：943 / 946

页数：4

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