Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats

被引：208

作者：

Ammann, P ^{[1
]}

Shen, V

Robin, B

Mauras, Y

Bonjour, JP

Rizzoli, R

机构：

[1] Univ Hosp Geneva, WHO, Ctr Osteoporosis Prevent, Dept Rehabil & Geriatr,Serv Bone Dis, CH-1211 Geneva 14, Switzerland

[2] Skeletech Inc, Bothell, WA USA

[3] Servier, Courbevoie, France

[4] Pharmacol & Toxicol Lab, Angers, France

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 12期

关键词：

strontium ranelate; rat; bone biomechanics; bone histomorphometry; bone quality;

D O I：

10.1359/JBMR.040906

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Strontium ranelate given to intact rats at doses up to 900 mg/kg/day increases bone resistance, cortical and trabecular bone volume, micro-architecture, bone mass, and total ALP activity, thus indicating a bone-forming activity and an improvement of overall bone tissue quality.

引用

页码：2012 / 2020

页数：9

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