Potential hazards of hexavalent chromate in our drinking water

被引:527
作者
Costa, M [1 ]
机构
[1] NYU, Inst Canc, Sch Med, Dept Environm Med,Dept Pharmacol, New York, NY 10016 USA
关键词
chromium; cancer; cellular uptake; reduction;
D O I
10.1016/S0041-008X(03)00011-5
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A consideration of the consequences of human exposure to hexavalent Cr in the drinking water has been compiled. Since there is an absence of adequate human data on this subject the problem has been analyzed not only from human and animal studies but also from a mechanistic point of view. This treatise has been inspired by recent reviews and speculations that suggest that we may safely drink hexavalent Cr in great excess of the current EPA and states drinking water standards of 50-100 ppb. (C) 2003 Elsevier Science (USA). All rights reserved.
引用
收藏
页码:1 / 5
页数:5
相关论文
共 28 条
[1]   Activation of gene expression by metal-responsive signal transduction pathways [J].
Adams, TK ;
Saydam, N ;
Steiner, F ;
Schaffner, W ;
Freedman, JH .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2002, 110 :813-817
[2]   UPTAKE OF CHROMATE IN HUMAN RED-BLOOD-CELLS AND ISOLATED RAT-LIVER CELLS - THE ROLE OF THE ANION CARRIER [J].
ALEXANDER, J ;
AASETH, J .
ANALYST, 1995, 120 (03) :931-933
[3]   Cytogenetic effects of hexavalent chromium in Bulgarian chromium platers [J].
Benova, D ;
Hadjidekova, V ;
Hristova, R ;
Nikolova, T ;
Boulanova, M ;
Georgieva, I ;
Grigorova, M ;
Popov, T ;
Panev, T ;
Georgieva, R ;
Natarajan, AT ;
Darroudi, F ;
Nilsson, R .
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2002, 514 (1-2) :29-38
[4]   Chromium picolinate toxicity [J].
Cerulli, J ;
Grabe, DW ;
Gauthier, I ;
Malone, M ;
McGoldrick, MD .
ANNALS OF PHARMACOTHERAPY, 1998, 32 (04) :428-431
[5]   MECHANISMS OF CHROMIUM CARCINOGENICITY AND TOXICITY [J].
COHEN, MD ;
KARGACIN, B ;
KLEIN, CB ;
COSTA, M .
CRITICAL REVIEWS IN TOXICOLOGY, 1993, 23 (03) :255-281
[6]   Toxicity and carcinogenicity of Cr(VI) in animal models and humans [J].
Costa, M .
CRITICAL REVIEWS IN TOXICOLOGY, 1997, 27 (05) :431-442
[7]  
Devi KD, 2001, FOOD CHEM TOXICOL, V39, P859
[8]   Molecular mechanisms of Cr(VI)-induced carcinogenesis [J].
Ding, M ;
Shi, XL .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2002, 234 (01) :293-300
[9]   Human ingestion of chromium(VI) in drinking water: Pharmacokinetics following repeated exposure [J].
Finley, BL ;
Kerger, BD ;
Katona, MW ;
Gargas, ML ;
Corbett, GC ;
Paustenbach, DJ .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1997, 142 (01) :151-159
[10]   Involvement of Erks activation in cadmium-induced AP-1 transactivation in vitro and in vivo [J].
Huang, CS ;
Zhang, QW ;
Li, JX ;
Shi, XL ;
Castranova, V ;
Ju, G ;
Costa, M ;
Dong, ZG .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2001, 222 (1-2) :141-147