Inhibition of lysine biosynthesis: an evolving antibiotic strategy

被引：139

作者：

Hutton, Craig A. ^{[1
]}

Perugini, Matthew A.

Gerrard, Juliet A.

机构：

[1] Univ Melbourne, Sch Chem, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Bio21 Mol Sci & Biotechnol Inst, Parkville, Vic 3010, Australia

[3] Univ Melbourne, Dept Biochem & Mol Biol, Parkville, Vic 3010, Australia

[4] Univ Canterbury, Sch Biol Sci, Christchurch 1, New Zealand

来源：

MOLECULAR BIOSYSTEMS | 2007年 / 3卷 / 07期

关键词：

D O I：

10.1039/b705624a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides lysine for protein synthesis and both lysine and meso-diaminopimelate for construction of the bacterial peptidoglycan cell wall. In this Highlight article we review recent advances in the validation of antibiotic targets, studies of the enzymes of the lysine biosynthetic pathway and development of inhibitors of these enzymes.

引用

页码：458 / 465

页数：8

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