Frontotemporal lobar degeneration with motor neuron disease-type inclusions predominates in 76 cases of frontotemporal degeneration

被引:151
作者
Lipton, AM
White, CL
Bigio, EH
机构
[1] Univ Texas, SW Med Sch, Dept Neurol, Dallas, TX 75390 USA
[2] Univ Texas, SW Med Sch, Dept Pathol, Dallas, TX 75390 USA
[3] Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA
关键词
frontotemporal dementia; frontotemporal lobar degeneration; motor neuron disease; ubiquitin;
D O I
10.1007/s00401-004-0900-9
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
This report presents the largest series of consecutive, neuropathologically confirmed cases of frontotemporal degeneration (FTD). Prior studies have found dementia lacking distinctive histology (DLDH) to be the most common pathology underlying the clinical diagnosis of FTD. In this series of 76 cases, 29 (38%) were found to have frontotemporal lobar degeneration with motor neuron disease-type inclusions (FTLD-MND-type) or FTLD-MND (with ALS), the most common neuropathological classification in our series. Only eight (11%) were classified as Pick's disease. Several cases originally designated as DLDH could be reclassified as FTLD-MND-type based on current recommendations for classification of FTD.
引用
收藏
页码:379 / 385
页数:7
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