Staphylococcus aureus;
Enterococcus faecalis;
sex pheromone;
quorum sensing;
gene transfer;
D O I:
10.1016/S0378-1097(97)00484-9
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
The long known fact that Staphylococcus aureus can secrete a peptide (staph-cAM373) which acts as a sex pheromone for strains of E. faecalis carrying the sex pheromone plasmid pAM373 was studied in detail. 85 of 100 independent isolates of S. aureus produced an activity inducing the pAM373 encoded adhesin resulting in a clumping reaction of E. faecalis (i.e. secreted staph-cAM373), but not a single one of 100 independent isolates of coagulase-negative Staphylococci possessed this activity. The production of peptides acting as sex pheromone for E. faecalis was observed only for sex pheromone plasmid pAM373, but not for sex pheromone plasmids pAD1 and pPD1. It was shown that the amount of staph-pAM373 produced during growth paralleled cell mass; therefore this peptide should not be used as a cell density indicator by S. aureus (i.e. has no quorum sensing Function). The potential function of staph-cAM373 to trigger gene transfer from Escherichia faecalis to S. aureus is discussed.
机构:
NYU, MED CTR, SKIRBALL INST, MOLEC PATHOGENESIS PROGRAM, NEW YORK, NY 10016 USANYU, MED CTR, SKIRBALL INST, MOLEC PATHOGENESIS PROGRAM, NEW YORK, NY 10016 USA
BALABAN, N
;
NOVICK, RP
论文数: 0引用数: 0
h-index: 0
机构:
NYU, MED CTR, SKIRBALL INST, MOLEC PATHOGENESIS PROGRAM, NEW YORK, NY 10016 USANYU, MED CTR, SKIRBALL INST, MOLEC PATHOGENESIS PROGRAM, NEW YORK, NY 10016 USA
机构:
KANSAS STATE UNIV,COLL VET MED,DEPT DIAGNOST MED PATHOBIOL,MANHATTAN,KS 66506KANSAS STATE UNIV,COLL VET MED,DEPT DIAGNOST MED PATHOBIOL,MANHATTAN,KS 66506
Crupper, SS
;
Iandolo, JJ
论文数: 0引用数: 0
h-index: 0
机构:
KANSAS STATE UNIV,COLL VET MED,DEPT DIAGNOST MED PATHOBIOL,MANHATTAN,KS 66506KANSAS STATE UNIV,COLL VET MED,DEPT DIAGNOST MED PATHOBIOL,MANHATTAN,KS 66506
机构:
NYU, MED CTR, SKIRBALL INST, MOLEC PATHOGENESIS PROGRAM, NEW YORK, NY 10016 USANYU, MED CTR, SKIRBALL INST, MOLEC PATHOGENESIS PROGRAM, NEW YORK, NY 10016 USA
BALABAN, N
;
NOVICK, RP
论文数: 0引用数: 0
h-index: 0
机构:
NYU, MED CTR, SKIRBALL INST, MOLEC PATHOGENESIS PROGRAM, NEW YORK, NY 10016 USANYU, MED CTR, SKIRBALL INST, MOLEC PATHOGENESIS PROGRAM, NEW YORK, NY 10016 USA
机构:
KANSAS STATE UNIV,COLL VET MED,DEPT DIAGNOST MED PATHOBIOL,MANHATTAN,KS 66506KANSAS STATE UNIV,COLL VET MED,DEPT DIAGNOST MED PATHOBIOL,MANHATTAN,KS 66506
Crupper, SS
;
Iandolo, JJ
论文数: 0引用数: 0
h-index: 0
机构:
KANSAS STATE UNIV,COLL VET MED,DEPT DIAGNOST MED PATHOBIOL,MANHATTAN,KS 66506KANSAS STATE UNIV,COLL VET MED,DEPT DIAGNOST MED PATHOBIOL,MANHATTAN,KS 66506