Formation of viscoelastic protein droplets on a chemically functionalized surface

被引：3

作者：

Belegrinou, S. ^{[1
]}

Mannelli, I. ^{[1
]}

Sirghi, L. ^{[1
]}

Bretagnol, F. ^{[1
]}

Valsesia, A. ^{[1
]}

Rauscher, H. ^{[1
]}

Rossi, F. ^{[1
]}

机构：

[1] Commiss European Communities, Joint Res Ctr, Inst Hlth & Consumer Protect, I-21020 Ispra, Italy

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2007年 / 111卷 / 30期

关键词：

D O I：

10.1021/jp073297x

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Droplet formation during adsorption of the protein lactoferrin from an aqueous solution on a surface functionalized by plasma deposited poly(acrylic acid) is studied using quartz crystal microbalance and atomic force microscopy. The formation of protein droplets is particularly favored at pH values close to the isoelectric point of lactoferrin, where the molecules carry little excess charge and intermolecular attraction exceeds the molecule-surface interaction. By combining topographic data with information on the system dynamics, it is possible to describe the viscoelastic properties of the adsorbate within a quantitative model for nonhomogeneous layers.

引用

页码：8713 / 8716

页数：4

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