Selfish DNA in protein-coding genes of Rickettsia

被引：86

作者：

Ogata, H

Audic, S

Barbe, V

Artiguenave, F

Fournier, PE

Raoult, D

Claverie, JM

机构：

[1] CNRS AVENTIS UMR 1889, F-13402 Marseille, France

[2] Ctr Natl Sequencage, F-91000 Evry, France

[3] Univ Mediterranee, Fac Med, Unite Rickettsies, CNRS UPRES A 6020, F-13385 Marseille, France

来源：

SCIENCE | 2000年 / 290卷 / 5490期

关键词：

D O I：

10.1126/science.290.5490.347

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Rickettsia conorii, the aetiological agent of Mediterranean spotted fever, is an intracellular bacterium transmitted by ticks. Preliminary analyses of the nearly complete genome sequence of R. conorii have revealed 44 occurrences of a previously undescribed palindromic repeat (150 base pairs Long) throughout the genome. Unexpectedly, this repeat was found inserted in-frame within 19 different R. conorii open reading frames likely to encode functional proteins. We found the same repeat in proteins of other Rickettsia species. The finding of a mobile element inserted in many unrelated genes suggests the potential role of selfish DNA in the creation of new protein sequences.

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页码：347 / 350

页数：4

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