A metabonomic study of strain- and age-related differences in the Zucker rat

被引：36

作者：

Granger, Jennifer H.

Williams, Rebecca

Lenz, Eva M.

Plumb, Robert S.

Stumpf, Chris L.

Wilson, Ian D.

机构：

[1] Arizona State Univ, Biodesign Inst, Tempe, AZ 85287 USA

[2] Novartis Inst BioMed Res, Cambridge, MA 02139 USA

[3] AstraZeneca R&D Boston, Waltham, MA 02451 USA

[4] AstraZeneca, Dept Drug Metab & Pharmacokinet, Macclesfield SK10 4TG, Cheshire, England

[5] Waters Corp, Milford, MA 01757 USA

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2007年 / 21卷 / 13期

关键词：

D O I：

10.1002/rcm.3059

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Ultra-performance liquid chromatography (UPLC) coupled to orthogonal acceleration time-of-flight mass spectrometry (oa-TOFMS) in positive electrospray ionization mode was used to obtain metabolite profiles for urine obtained from three strains of Zucker rat. These were the Zucker lean, the Zucker (fa/fa) obese and the Zucker lean/(fa) cross. Clear age- and strain-related differences were noted with the leptin-deficient (fa/fa) obese animal showing significant differences from both the other Zucker rat strains with respect to metabolite profiles. Copyright (C) 2007 John Wiley & Sons, Ltd.

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页码：2039 / 2045

页数：7

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