No evidence for association of the dysbindin gene [DTNBP1] with schizophrenia in an Irish population-based study

被引：69

作者：

Morris, DW ^{[1
]}

McGhee, KA

Schwaiger, S

Scully, P

Quinn, J

Meagher, D

Gill, M

Corvin, AP

机构：

[1] Trinity Coll Dublin, Dept Genet, Neuropsychiat Genet Grp, Dublin 2, Ireland

[2] St Davnet Hosp, Stanley Res Unit, Monaghan, Ireland

[3] Royal Coll Surgeons Ireland, Dept Clin Pharmacol, Dublin 2, Ireland

来源：

SCHIZOPHRENIA RESEARCH | 2003年 / 60卷 / 2-3期

关键词：

schizophrenia; dysbindin; DTNBP1; association;

D O I：

10.1016/S0920-9964(02)00527-3

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

A recent family-based association study identified a putative association between variants in the dystrobrevin binding protein 1 (dysbindin) gene (DTNBP1) and schizophrenia. This study used a sample of 270 Irish pedigrees multiply affected with schizophrenia. We attempted to replicate these findings in an independent Irish sample of 219 schizophrenia cases and 231 controls. No evidence was found to suggest an association between the DTNBP1 gene and schizophrenia in our sample. Possible reasons for these findings are discussed. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：167 / 172

页数：6

共 18 条

[1] Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain
Benson, MA
Newey, SE
Martin-Rendon, E
Hawkes, R
Blake, DJ
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (26) : 24232 - 24241
[2] A major susceptibility gene for asthma maps to chromosome 14q24
Hakonarson, H
Bjornsdottir, US
Halapi, E
Palsson, S
Adalsteinsdottir, E
Gislason, D
Finnbogason, G
Gislason, T
Kristjansson, K
Arnason, T
Birkisson, I
Frigge, ML
Kong, A
Gulcher, JR
Stefansson, K
[J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 71 (03) : 483 - 491
[3] Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Hugot, JP
Chamaillard, M
Zouali, H
Lesage, S
Cézard, JP
Belaiche, J
Almer, S
Tysk, C
O'Morain, CA
Gassull, M
Binder, V
Finkel, Y
Cortot, A
Modigliani, R
Laurent-Puig, P
Gower-Rousseau, C
Macry, J
Colombel, JF
Sahbatou, M
Thomas, G
[J]. NATURE, 2001, 411 (6837) : 599 - 603
[4] Hwu HG, 2000, AM J MED GENET, V96, P74, DOI 10.1002/(SICI)1096-8628(20000207)96:1<74::AID-AJMG15>3.0.CO
[5] 2-G
[6] THE SPORADIC V FAMILIAL CLASSIFICATION GIVEN ETIOLOGICAL HETEROGENEITY .2. POWER ANALYSES
KENDLER, KS
[J]. PSYCHOLOGICAL MEDICINE, 1988, 18 (04) : 991 - 999
[7] ALLELIC ASSOCIATION OF THE CYSTIC-FIBROSIS LOCUS AND 2 DNA MARKERS, XV2C AND KM19, IN 55 GERMAN FAMILIES
KRAWCZAK, M
KONECKI, DS
SCHMIDTKE, J
DUCK, M
ENGEL, W
NUTZENADEL, W
TREFZ, FK
[J]. HUMAN GENETICS, 1988, 80 (01) : 78 - 80
[8] Levinson DF, 1996, AM J MED GENET, V67, P580
[9] LEVINSON DF, 2002, AM J MED GENET, V114, P697
[10] LEWONTIN RC, 1964, GENETICS, V49, P49

← 1 2 →