Retroviral restriction by APOBEC proteins

被引：525

作者：

Harris, RS ^{[1
]}

Liddament, MT ^{[1
]}

机构：

[1] Univ Minnesota, Biochem Mol Biol & Biophys Dept, Minneapolis, MN 55455 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2004年 / 4卷 / 11期

关键词：

D O I：

10.1038/nri1489

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A powerful mechanism of vertebrate innate immunity has been discovered in the past year, in which APOBEC proteins inhibit retroviruses by deaminating cytosine residues in nascent retroviral cDNA. To thwart this cellular defence, HIV encodes Vif, a small protein that mediates APOBEC degradation. Therefore, the balance between APOBECs and Vif might be a crucial determinant of the outcome of retroviral infection. Vertebrates have up to 11 different APOBEC proteins, with primates having the most. APOBEC proteins include AID, a probable DNA mutator that is responsible for immunoglobulin-gene diversification, and APOBEC1, an RNA editor with antiretroviral activities. This APOBEC abundance might help to tip the balance in favour of cellular defences.

引用

页码：868 / 877

页数：10

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