Amino Acids from Mytilus galloprovincialis (L.) and Rapana venosa Molluscs Accelerate Skin Wounds Healing via Enhancement of Dermal and Epidermal Neoformation

被引:30
作者
Badiu, Diana L. [1 ]
Luque, Rafael [2 ]
Dumitrescu, Elena [3 ]
Craciun, Anca [4 ]
Dinca, Danut [5 ]
机构
[1] Ovidius Univ Constanta, Dept Biol Biochem, Fac Nat & Agr Sci, Constanta 900527, Romania
[2] Univ Cordoba, Dept Organ Chem, E-14004 Cordoba, Spain
[3] Natl Inst Recovery Phys Med & Clin Balneary, Bucharest, Romania
[4] Constanta Clin Emergency Hosp, Phatol Anat Lab, Constanta 900591, Romania
[5] Constanta Clin Emergency Hosp, Dept Otorhinolaryngol, Constanta 900591, Romania
关键词
Amino acids; Histological; Skin; Mytilus galloprovincialis (L.); Rapana venosa; PLASMA;
D O I
10.1007/s10930-009-9225-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
Wound healing consists of re-epithelialization, contraction and formation of granulation and scar tissue. Amino acids from proteins are involved in these events, but their exact roles are not well understood. The present study was undertaken to investigate the anti-inflammatory effects of some amino acids from two molluscs, Mytilus galloprovincialis (L.) (Mediterranean mussel) and Rapana venosa (hard shell-clam) employed in induced skin burn injuries in Wistar rats. The treatment was evaluated in terms of essential amino acids composition which rendered the extracts very efficient in healing skin burns. The healing process was examined by periodic acid Schiff's, Verhoeff's Van Gieson and immunohistochemistry stains for collagen IV, CD 34 and CD 117 antibodies. According to the obtained results, as expressed by histological studies, the most abundant blood vessels, collagen fibres, basal and stem cells were found only for treated animals with amino acids from Rapana venosa extracts. The rich composition of amino acids from the two molluscs merits consideration as therapeutic agents in the treatment of skin burns.
引用
收藏
页码:81 / 92
页数:12
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