Rapid in vivo screening of experimental drugs for tuberculosis using gamma interferon gene-disrupted mice

被引：88

作者：

Lenaerts, AJM ^{[1
]}

Gruppo, V ^{[1
]}

Brooks, JV ^{[1
]}

Orme, IM ^{[1
]}

机构：

[1] Colorado State Univ, Dept Microbiol, Ft Collins, CO 80523 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 02期

关键词：

D O I：

10.1128/AAC.47.2.783-785.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have developed a rapid new in vivo method for screening experimental drugs for their activity against Mycobacterium tuberculosis by using the gamma interferon gene-disrupted (GKO) C57BL/6 mouse. Due to the rapid growth of the infection, statistical differences indicating positive efficacy of active compounds can be seen after only 8 days of treatment. To validate this model, several fluoroquinolones, including ciprofloxacin, levofloxacin, moxifloxacin, and gatifloxacin, were tested in parallel.

引用

页码：783 / 785

页数：3

共 19 条

[1] The value of in vitro drug activity and pharmacokinetics in predicting the effectiveness of antimycobacterial therapy: A critical review [J].

Burman, WJ .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1997, 313 (06) :355-363

[2]

CANETTI G, 1963, Tubercle, V44, P236, DOI 10.1016/S0041-3879(63)80118-X

[3] DISSEMINATED TUBERCULOSIS IN INTERFERON-GAMMA GENE-DISRUPTED MICE [J].

COOPER, AM ;

DALTON, DK ;

STEWART, TA ;

GRIFFIN, JP ;

RUSSELL, DG ;

ORME, IM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (06) :2243-2247

[4] Activities of several novel oxazolidinones against Mycobacterium tuberculosis in a murine model [J].

Cynamon, MH ;

Klemens, SP ;

Sharpe, CA ;

Chase, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (05) :1189-1191

[5] MULTIPLE DEFECTS OF IMMUNE CELL-FUNCTION IN MICE WITH DISRUPTED INTERFERON-GAMMA GENES [J].

DALTON, DK ;

PITTSMEEK, S ;

KESHAV, S ;

FIGARI, IS ;

BRADLEY, A ;

STEWART, TA .

SCIENCE, 1993, 259 (5102) :1739-1742

[6]

Dickinson J M, 1968, Tubercle, V49, P351, DOI 10.1016/S0041-3879(68)80016-9

[7]

DICKINSON J M, 1970, Tubercle, V51, P82, DOI 10.1016/0041-3879(70)90131-5

[8] AN ESSENTIAL ROLE FOR INTERFERON-GAMMA IN RESISTANCE TO MYCOBACTERIUM-TUBERCULOSIS INFECTION [J].

FLYNN, JL ;

CHAN, J ;

TRIEBOLD, KJ ;

DALTON, DK ;

STEWART, TA ;

BLOOM, BR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (06) :2249-2254

[9] STERILIZING VALUE OF RIFAMPICIN AND PYRAZINAMIDE IN EXPERIMENTAL SHORT COURSE CHEMOTHERAPY [J].

GROSSET, J .

TUBERCLE, 1978, 59 (04) :287-297

[10]

Grumbach F, 1967, Rev Tuberc Pneumol (Paris), V31, P749

← 1 2 →