2J, 3J-HMBC:: A new long-range heteronuclear shift correlation technique capable of differentiating 2JCH from 3JCH correlations to protonated carbons

被引：58

作者：

Krishnamurthy, VV

Russell, DJ

Hadden, CE

Martin, GE ^{[1
]}

机构：

[1] Varian Inc, NMR Applicat Lab, Palo Alto, CA 94303 USA

[2] Pharmacia & Upjohn Inc, Pharmaceut Dev, Rapid Struct Characterizat Grp, Kalamazoo, MI 49001 USA

来源：

JOURNAL OF MAGNETIC RESONANCE | 2000年 / 146卷 / 01期

关键词：

accordion excitation; long-range heteronuclear shift correlation; (2)J; (3)J-HMBC; constant time variable delay; STAR operator;

D O I：

10.1006/jmre.2000.2141

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The development of a series of new, accordion-optimized long-range heteronuclear shift correlation techniques has been reported. A further derivative of the constant time variable delay introduced in the IMPEACH-MBC experiment, a STAR (Selectively Tailored Accordion F-1 Refocusing) operator is described in the present report. Incorporation of the STAR operator with the capability of user-selected homonuclear modulation scaling as in the CIGAR-HMBC experiment, into a long-range heteronuclear shift correlation pulse sequence, (2)J,(3)J-HMBC, affords for the first time in a proton-detected experiment the means of unequivocally differentiating two-bond ((2)J(CH)) from three-bond ((3)J(CH)) long-range correlations to protonated carbons. (C) 2000 Academic Press.

引用

页码：232 / 239

页数：8

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