Serum nitrate and NOx levels in preeclampsia are higher than in normal pregnancy

被引：13

作者：

Acauan Filho, Breno Jose ^{[1
]}

Pinheiro da Costa, Bartira Ercilia ^{[1
]}

Ogando, Patricia Barcelos ^{[1
]}

Vieira, Matias Costa ^{[1
]}

Antonello, Ivan Carlos ^{[1
]}

Poli-de-Figueiredo, Carlos Eduardo ^{[1
]}

机构：

[1] Pontificia Univ Catolica Rio Grande do Sul, Hosp Sao Lucas, Programa Posgrad Med & Ciencias Saude, Inst Pesquisas Biomed,Fac Med, Porto Alegre, RS, Brazil

来源：

HYPERTENSION IN PREGNANCY | 2016年 / 35卷 / 02期

关键词：

Cyclic GMP; endothelium-dependent relaxing factors; hypertension; nitrite; pregnancy-induced; vasodilatation; ARGININE ERYTHROCYTE TRANSPORT; NITRIC-OXIDE SYNTHESIS; BLOOD-PRESSURE; CYCLIC-GMP; SMALL ARTERIES; WOMEN; HYPERTENSION; SILDENAFIL; INHIBITOR; SUPPLEMENTATION;

D O I：

10.3109/10641955.2016.1139718

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

Objectives: To compare nitric oxide (NO) serum levels in women with and without preeclampsia. Methods: 106 women were classified into preeclampsia group (n = 40) and normotensive group (n = 66). NO content was measured in the serum. Clinical and laboratorial data were recorded for comparison. Results: Preeclampsia presented a significant increase in nitrate and NOx levels compared to the control group. Uric acid, gestational age, systolic and diastolic blood pressure, and creatinine showed correlation with nitrates and NOx. Conclusion: Increase of NO was observed in preeclampsia women. Failure in the mechanism of action, dependent on cyclic GMP, may justify this finding.

引用

页码：226 / 233

页数：8

共 47 条

[1]

Plasma nitric oxide, endothelin-1 and urinary nitric oxide and cyclic guanosine monophosphate levels in hypertensive pregnant women [J].