CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells

被引：282

作者：

Wong, FS

Visintin, I

Wen, L

Flavell, RA

Janeway, CA

机构：

[1] YALE UNIV,SCH MED,HOWARD HUGHES MED INST,IMMUNOBIOL SECT,NEW HAVEN,CT 06510

[2] YALE UNIV,DEPT BIOL,NEW HAVEN,CT 06510

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1996年 / 183卷 / 01期

关键词：

D O I：

10.1084/jem.183.1.67

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cells play an important role in the pathogenesis of diabetes in the nonobese diabetic (NOD) mouse. CDS cytotoxic T cell lines and clones were generated from the lymphocytic infiltrate in the islets of langerhans of young (7-wk-old) NOD mice by growing them on (NOD X B6-RIP-B7-1)F-1 islets. These cells proliferate specifically to NOD islets and kill NOD islets in vitro. The cells are restricted by H-2K(d), and all bear T cell antigen receptor encoded by V beta 6. When these CD8 T cell Lines and clones are adoptively transferred to irradiated female NOD, young NOD-SCID, and CB17-SCID mice, diabetes occurs very rapidly, within 10 d of transfer and without CD4 T cells.

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页码：67 / 76

页数：10

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