The Na+/H+ exchanger isoform 1

被引：103

作者：

Fliegel, L ^{[1
]}

机构：

[1] Univ Alberta, Canadian Inst Hlth Res Membrane Prot Res Grp, Edmonton, AB T6G 2H7, Canada

[2] Univ Alberta, Dept Biochem, Edmonton, AB T6G 2H7, Canada

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2005年 / 37卷 / 01期

关键词：

cation transport; membrane; Na+/H+ exchanger; pH regulation;

D O I：

10.1016/j.biocel.2004.02.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Na+/H+ exchanger (NHE) isoform 1 is a ubiquitously expressed integral membrane protein which regulates intracellular pH in mammalian cells. Nine isoforms of the Na+/H+ exchanger have been identified. The isoform first discovered has two domains: an N-terminal membrane domain containing approximately 500 amino acids and a C-terminal regulatory domain containing approximately 315 amino acids. The exchanger, which resides in the plasma membrane, exchanges an intracellular proton for an extracellular sodium, thereby regulating intracellular pH. It is involved in cell growth and differentiation, cell migration, and regulation of sodium fluxes. The Na+/H+ exchanger plays an important role in myocardial damage during ischemia and reperfusion and has recently been implicated Lis a mediator of cardiac hypertrophy. Inhibitors of the Na+/H+ exchanger, which may prove useful in the clinical treatment of these conditions, are currently being developed and clinical trials are underway. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：33 / 37

页数：5

共 24 条

[1] Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures [J].

Bell, SM ;

Schreiner, CM ;

Schultheis, PJ ;

Miller, ML ;

Evans, RL ;

Vorhees, CV ;

Shull, GE ;

Scott, WJ .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1999, 276 (04) :C788-C795

[2] Random mutagenesis reveals a novel site involved in inhibitor interaction within the fourth transmembrane segment of the Na+/H+ exchanger-1 [J].

Counillon, L ;

Noel, J ;

Reithmeier, RAF ;

Pouyssegur, J .

BIOCHEMISTRY, 1997, 36 (10) :2951-2959

[3] A POINT MUTATION OF THE NA+/H+ EXCHANGER GENE (NHE1) AND AMPLIFICATION OF THE MUTATED ALLELE CONFER AMILORIDE RESISTANCE UPON CHRONIC ACIDOSIS [J].

COUNILLON, L ;

FRANCHI, A ;

POUYSSEGUR, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (10) :4508-4512

[4] Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice [J].

Cox, GA ;

Lutz, CM ;

Yang, CL ;

Biemesderfer, D ;

Bronson, RT ;

Fu, A ;

Aronson, PS ;

Noebels, JL ;

Frankel, WN .

CELL, 1997, 91 (01) :139-148

[5] Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1 [J].

Denker, SP ;

Barber, DL .

JOURNAL OF CELL BIOLOGY, 2002, 159 (06) :1087-1096

[6]

Karmazyn M, 2003, SODIUM-HYDROGEN EXCHANGER: FROM MOLECULE TO ITS ROLE IN DISEASE, P221

[7]

KARMAZYN M, 2003, NAPLUS HPLUS EXCHANG, P211

[8] Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization [J].

Khaled, AR ;

Moor, AN ;

Li, AQ ;

Ferris, DK ;

Muegge, K ;

Fisher, RJ ;

Fliegel, L ;

Durum, SK .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (22) :7545-7557

[9] The Na+/H+ exchanger cytoplasmic tail:: Structure, function, and interactions with tescalcin [J].

Li, XJ ;

Liu, YS ;

Kay, CM ;

Müller-Esterl, W ;

Fliegel, L .

BIOCHEMISTRY, 2003, 42 (24) :7448-7456

[10] Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger [J].

Li, XJ ;

Alvarez, B ;

Casey, JR ;

Reithmeier, RAF ;

Fliegel, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (39) :36085-36091

← 1 2 3 →