Evolutionary origin of the medaka Y chromosome

被引:115
作者
Kondo, M
Nanda, I
Hornung, U
Schmid, M
Schartl, M [1 ]
机构
[1] Univ Wurzburg, Dept Physiol Chem 1, D-97074 Wurzburg, Germany
[2] Univ Wurzburg, Inst Human Genet, D-97074 Wurzburg, Germany
关键词
D O I
10.1016/j.cub.2004.09.026
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Genetic sex determination in an XX-XY chromosome system can be realized through a locus on the Y chromosome that makes the undifferentiated gonad develop into a testis. Although this mechanism is widespread, only in two cases so far have the corresponding master male sex-determining genes been identified. One is Sry [1-5], which initiates testes determination in most mammals. The other is dmrt1 bY [6, 7] (syn. dmy), from the fish medaka, Oryzias latipes. The mammalian Y is roughly estimated to be over 200 million years old [8]. The medaka Y may be considerably younger [6, 9]. A comparative analysis of the genus Oryzias revealed that one sister species of the medaka has dmrt1bY on a homologous Y chromosome, whereas in another closely related species only a non-sex-linked pseudogene is present. In all other species, dmrt1bY was not detected. The divergence time for the different species was determined with mitochondrial DNA sequences. The timing was confirmed by independent calculations based on dmrt1 sequences. We show that the medaka sex-determining gene originated approximately 10 million years ago. This makes dmrt1 bY and the corresponding Y chromosome the youngest male sex-determining system, at least in vertebrates, known so far.
引用
收藏
页码:1664 / 1669
页数:6
相关论文
共 43 条
[1]   Isolation of DNA suitable for PCR for field and laboratory work [J].
Altschmied, J ;
Hornung, U ;
Schlupp, I ;
Gadau, J ;
Kolb, R ;
Schartl, M .
BIOTECHNIQUES, 1997, 23 (02) :228-229
[2]  
[Anonymous], 2001, PHYLOGENETIC ANAL US
[3]   Genomic organization and expression of the doublesex-related gene cluster in vertebrates and detection of putative regulatory regions for DMRT1 [J].
Brunner, B ;
Hornung, U ;
Shan, Z ;
Nanda, I ;
Kondo, M ;
Zend-Ajusch, E ;
Haaf, T ;
Ropers, HH ;
Shima, A ;
Schmid, M ;
Kalscheuer, VM ;
Schartl, M .
GENOMICS, 2001, 77 (1-2) :8-17
[4]   THE EVOLUTION OF SEX-CHROMOSOMES [J].
CHARLESWORTH, B .
SCIENCE, 1991, 251 (4997) :1030-1033
[5]   The evolution of chromosomal sex determination and dosage compensation [J].
Charlesworth, B .
CURRENT BIOLOGY, 1996, 6 (02) :149-162
[6]  
Graves JAM, 2002, NOVART FDN SYMP, V244, P86
[7]  
Graves JAM, 1998, BIOESSAYS, V20, P264, DOI 10.1002/(SICI)1521-1878(199803)20:3&lt
[8]  
264::AID-BIES10&gt
[9]  
3.0.CO
[10]  
2-1