The many faces of filamin: A versatile molecular scaffold for cell motility and signalling

被引：414

作者：

Feng, YY ^{[1
]}

Walsh, CA ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Howard Hughes Med Inst,Dept Neurol, Boston, MA 02115 USA

来源：

NATURE CELL BIOLOGY | 2004年 / 6卷 / 11期

关键词：

D O I：

10.1038/ncb1104-1034

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Filamins were discovered as the first family of non-muscle actin-binding protein. They are lage cytoplasmic proteins that crosslink cortical actin into a dynamic three-dimensional structure. Filamins have also been reported to interact with a large number of cellular proteins of great functional diversity, suggesting that they are unusually versatile signalling scaffolds. More recently, genetic mutations in filamin A and B have been reported to cause a wide range of human diseases, suggesting that different diseases highlight distinct filamin interactions.

引用

收藏

页码：1034 / 1038

页数：5

相关论文

共 38 条

[1]

BROTSCHI EA, 1978, J BIOL CHEM, V253, P8988

[2] Increased filamin binding to β-integrin cytoplasmic domains inhibits cell migration [J].

Calderwood, DA ;

Huttenlocher, A ;

Kiosses, WB ;

Rose, DM ;

Woodside, DG ;

Schwartz, MA ;

Ginsberg, MH .

NATURE CELL BIOLOGY, 2001, 3 (12) :1060-1068

[3] OSTEODYSPLASTY - (MELNICK AND NEEDLES SYNDROME) - REPORT OF A CASE [J].

COSTE, F ;

MAROTEAUX, P ;

CHOURAKI, L .

ANNALS OF THE RHEUMATIC DISEASES, 1968, 27 (04) :360-+

[4] OTO-PALATO-DIGITAL SYNDROME - A NEW SYMPTOM-COMPLEX CONSISTING OF DEAFNESS DWARFISM CLEFT PALATE CHARACTERISTIC FACIES AND A GENERALIZED BONE DYSPLASIA [J].

DUDDING, BA ;

GORLIN, RJ ;

LANGER, LO .

AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1967, 113 (02) :214-&

[5] Periventricular heterotopia: An X-linked dominant epilepsy locus causing aberrant cerebral cortical development [J].

Eksioglu, YZ ;

Scheffer, IE ;

Cardenas, P ;

Knoll, J ;

DiMario, F ;

Ramsby, G ;

Berg, M ;

Kamuro, K ;

Berkovic, SF ;

Duyk, GM ;

Parisi, J ;

Huttenlocher, PR ;

Walsh, CA .

NEURON, 1996, 16 (01) :77-87

[6] Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia [J].

Fox, JW ;

Lamperti, ED ;

Eksioglu, YZ ;

Hong, SE ;

Feng, YY ;

Graham, DA ;

Scheffer, IE ;

Dobyns, WB ;

Hirsch, BA ;

Radtke, RA ;

Berkovic, SF ;

Huttenlocher, PR ;

Walsh, CA .

NEURON, 1998, 21 (06) :1315-1325

[7] HUMAN ENDOTHELIAL ACTIN-BINDING PROTEIN (ABP-280, NONMUSCLE FILAMIN) - A MOLECULAR LEAF SPRING [J].

GORLIN, JB ;

YAMIN, R ;

EGAN, S ;

STEWART, M ;

STOSSEL, TP ;

KWIATKOWSKI, DJ ;

HARTWIG, JH .

JOURNAL OF CELL BIOLOGY, 1990, 111 (03) :1089-1105

[8] FRONTOMETAPHYSEAL DYSPLASIA - A NEW SYNDROME [J].

GORLIN, RJ ;

COHEN, MM .

AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1969, 118 (03) :487-&

[9] MELNICK-NEEDLES SYNDROME - RADIOGRAPHIC ALTERATIONS IN MANDIBLE [J].

GORLIN, RJ ;

LANGER, LO .

RADIOLOGY, 1978, 128 (02) :351-353

[10] Germline and mosaic mutations of FLN1 in men with periventricular heterotopia [J].

Guerrini, R ;

Mei, D ;

Sisodiya, S ;

Sicca, F ;

Harding, B ;

Takahashi, Y ;

Dorn, T ;

Yoshida, A ;

Campistol, J ;

Krämer, G ;

Moro, F ;

Dobyns, WB ;

Parrini, E .

NEUROLOGY, 2004, 63 (01) :51-56

← 1 2 3 4 →