NR4A nuclear receptors in atherosclerosis and vein-graft disease

被引：67

作者：

Bonta, Peter I. ^{[1
]}

Pols, Thijs W. H. ^{[1
]}

de Vries, Carlie J. M. ^{[1
]}

机构：

[1] Acad Med Ctr, Dept Biochem Med, NL-1105 AZ Amsterdam, Netherlands

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2007年 / 17卷 / 03期

关键词：

D O I：

10.1016/j.tcm.2007.02.001

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Nur77, Nurr1, and NOR-1 form the NR4A subfamily of the nuclear hormone receptor superfamily of transcription factors and have been described in the regulation of differentiation, proliferation, apoptosis, and survival of many different cell types. The expression of NR4A nuclear receptors in vascular pathologies has only recently been revealed, after which studies on the functional involvement of NR4A receptors in vascular disease were initiated. This review summarizes our current view on involvement of Nur77, Nurr1, and NOR-1 in atherosclerotic vascular disease and discusses NR4A function in vascular response to injury.

引用

页码：105 / 111

页数：7

共 54 条

[1]

TR3 orphan receptor is expressed in vascular endothelial cells and mediates cell cycle arrest [J].

Arkenbout, EK ;

van Bragt, M ;

Eldering, E ;

van Bree, C ;

Grimbergen, JM ;

Quax, PHA ;

Pannekoek, H ;

de Vries, CJM .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (09) :1535-1540

[2]

Protective function of transcription factor TR3 orphan receptor in atherogenesis - Decreased lesion formation in carotid artery ligation model in TR3 transgenic mice [J].

Arkenbout, EK ;

de Waard, V ;

van Bragt, M ;

van Achterberg, TAE ;

Grimbergen, JM ;

Pichon, B ;

Pannekoek, H ;

de Vries, CJM .

CIRCULATION, 2002, 106 (12) :1530-1535

[3]

Auwerx J, 1999, CELL, V97, P161

[4]

Peroxisome proliferator-activated receptors and liver X receptors in atherosclerosis and immunity [J].

Barish, GD .

JOURNAL OF NUTRITION, 2006, 136 (03) :690-694

[5]

A nuclear receptor atlas: Macrophage activation [J].

Barish, GD ;

Downes, M ;

Alaynick, WA ;

Yu, RT ;

Ocampo, CB ;

Bookout, AL ;

Mangelsdorf, DJ ;

Evans, RM .

MOLECULAR ENDOCRINOLOGY, 2005, 19 (10) :2466-2477

[6]

A role for the NGFI-B family in adrenal zonation and adrenocortical disease [J].

Bassett, MH ;

White, PC ;

Rainey, WE .

ENDOCRINE RESEARCH, 2004, 30 (04) :567-574

[7]

Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses [J].

Bonta, Peter I. ;

van Tiel, Claudia M. ;

Vos, Mariska ;

Pols, Thijs W. H. ;

van Thienen, Johannes V. ;

Ferreira, Valerie ;

Arkenbout, E. Karin ;

Seppen, Jurgen ;

Spek, C. Arnold ;

van der Poll, Tom ;

Pannekoek, Hans ;

de Vries, Carlie J. M. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2006, 26 (10) :2288-2294

[8]

Nuclear receptors in macrophage biology: At the crossroads of lipid metabolism and inflammation [J].

Castrillo, A ;

Tontonoz, P .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2004, 20 :455-480

[9]

Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis [J].

Cheng, LEC ;

Chan, FKM ;

Cado, D ;

Winoto, A .

EMBO JOURNAL, 1997, 16 (08) :1865-1875

[10]

Activation of Nur77 by selected 1,1-bis(3'-indolyl)-1-(p-substituted phenyl) methanes induces apoptosis through nuclear pathways [J].

Chintharlapalli, S ;

Burghardt, R ;

Papineni, S ;

Ramaiah, S ;

Yoon, K ;

Safe, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (26) :24903-24914

← 1 2 3 4 5 6 →