Plasma coagulation factor levels in venous thrombosis

被引：21

作者：

Nossent, A. Yael ^{[1
]}

Eikenboom, Jeroen C. J. ^{[1
]}

Bertina, Rogier M. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Ctr Hemostasis & Thrombosis Res, Dept Hematol, NL-2300 RC Leiden, Netherlands

来源：

SEMINARS IN HEMATOLOGY | 2007年 / 44卷 / 02期

关键词：

ACTIVATABLE FIBRINOLYSIS INHIBITOR; FACTOR-VIII LEVELS; VON-WILLEBRAND-FACTOR; DEEP-VEIN THROMBOSIS; ELEVATED FACTOR-VIII; TAFI-ANTIGEN LEVELS; PROTHROMBIN G20210A MUTATION; FACTOR-V-LEIDEN; FACTOR-XI; RISK-FACTORS;

D O I：

10.1053/j.seminhematol.2007.01.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

High plasma levels of several coagulation factors have been described to be associated with an increased risk of venous thrombosis. However, the mechanisms underlying these associations, as well as those involved in the regulation of plasma levels of coagulation factors, are mostly unknown. Whether these factors should be included in the workup of patients with venous thrombosis remains to be determined. In this review, we discuss the present knowledge on the effects of plasma levels of coagulation factors on the development of venous thrombosis. Furthermore, we review recent findings and ideas on the mechanisms through which elevated plasma coagulation factor levels may influence thrombosis. Finally, we enter into the matter of the possible determinants of elevated plasma levels of coagulation factors. © 2007 Elsevier Inc. All rights reserved.

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页码：77 / 84

页数：8

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