Human telomeric G-quadruplex: structures of DNA and RNA sequences

被引：442

作者：

Phan, Anh Tuan ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Phys & Appl Phys, Singapore 637371, Singapore

来源：

FEBS JOURNAL | 2010年 / 277卷 / 05期

关键词：

DNA; G-quadruplex; G-quadruplex structure; G-quadruplex topology; G-tetrad; G-tetrad core; grooves in G-quadruplexes; human telomere; loops in G-quadruplexes; RNA; INTRAMOLECULAR G-QUADRUPLEX; K+ SOLUTION; MAMMALIAN TELOMERES; LIGAND RECOGNITION; PARALLEL; BINDING; FORMS; TOPOLOGY; DYNAMICS; CRYSTAL;

D O I：

10.1111/j.1742-4658.2009.07464.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomeres play an important role in cellular aging and cancer. Human telomeric DNA and RNA G-rich sequences are capable of forming a four-stranded structure, known as the G-quadruplex. Such a structure might be important for telomere biology and a good target for drug design. This minireview describes the structural diversity or conservation of DNA and RNA human telomeric G-quadruplexes, discusses structural views on targeting these G-quadruplexes and presents some future challenges for structural studies.

引用

页码：1107 / 1117

页数：11

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