A link between protein acetylation and mitochondrial dynamics under energy metabolism: A comprehensive overview

被引：10

作者：

Gu, Huihui ^{[1
]}

Yang, Kun ^{[1
]}

Wu, Qiong ^{[1
,2
]}

Shen, Zhentong ^{[1
]}

Li, Xinjian ^{[3
]}

Sun, Chao ^{[1
]}

机构：

[1] Northwest A&F Univ, Key Lab Anim Genet, Breeding & Reprod Shaanxi Prov, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China

[2] Qinghai Univ, Dept Pathophysiol, Med Coll, Xining, Qinghai, Peoples R China

[3] Henan Agr Univ, Coll Anim Sci & Vet Med, Zhengzhou, Peoples R China

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2021年 / 236卷 / 12期

基金：

中国国家自然科学基金;

关键词：

energy metabolism; mitochondrial dynamics; protein acetylation; SIRT3; DEACETYLATES; LYSINE DEACETYLATION; INDUCED APOPTOSIS; MEMBRANE-FUSION; MITOFUSIN; FISSION; OPA1; DRP1; PHOSPHORYLATION; DISEASE;

D O I：

10.1002/jcp.30461

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Cells adjust mitochondrial morphologies to coordinate between the cellular demand for energy and the availability of resources. Mitochondrial morphology is regulated by the balance between two counteracting mitochondrial processes of fusion and fission. Fission and fusion are dynamic and reversible processes that depend on the coordination of a number of proteins and are primarily regulated by posttranslational modifications. In the mitochondria, more than 20% of proteins are acetylated in proteomic surveys, partly involved in the dynamic regulation of mitochondrial fusion and fission. This article focuses on the molecular mechanism of the mitochondrial dynamics of fusion and fission, and summarizes the related mechanisms and targets of mitochondrial protein acetylation to regulate the mitochondrial dynamics of fusion and fission in energy metabolism.

引用

收藏

页码：7926 / 7937

页数：12

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