Bioactive kaurane diterpenoids from Annona glabra

被引：68

作者：

Chang, FR

Yang, PY

Lin, JY

Lee, KH

Wu, YC ^{[1
]}

机构：

[1] Kaohsiung Med Coll, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Natl Taiwan Univ, Coll Med, Grad Inst Biochem, Taipei 10018, Taiwan

[3] Univ N Carolina, Sch Pharm, Div Med Chem & Nat Prod, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 04期

关键词：

D O I：

10.1021/np970497z

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Phytochemical analysis of the fruits of Annona glabra yielded two new kaurane diterpenoids, annoglabasin A (methyl-16 beta-acetoxy-19-al-ent-kauran-17-oate)(1) and annoglabasin B (16 alpha-hydro-19-acetoxy-ent-kauran-17-oic acid)(2), along with 11 known kaurane derivatives (3-13). The structures of the new compounds were established by spectral and chemical evidence. Among these, methyl-16 alpha-hydro-19-al-ent-kauran-17-oate (11) exhibited mild activity against HIV replication in H9 lymphocyte cells, and 16 alpha-17-dihydroxy-ent-kauran-19-oic acid (4) showed significant inhibition of HIV-reverse transcriptase.

引用

页码：437 / 439

页数：3

共 14 条

[1] ANTITUMOUR AND ANTIBIOTIC PRINCIPLES OF ANNONA-SENEGALENSIS [J].