Tau protein concentrations in cerebrospinal fluid of non-demented Parkinson's disease patients

被引：21

作者：

Molina, JA

Benito-León, J

Jiménez-Jiménez, FJ

Ortí-Pareja, M

Berbel, A

Tallón-Barranco, A

de Bustos, F

Hernánz, A

机构：

[1] Hosp Univ Doce Octubre, Dept Neurol, Madrid, Spain

[2] Univ Alcala de Henares, Hosp Principe Asturias, Neurol Sect, Madrid, Spain

[3] Hosp Univ Doce Octubre, Dept Biochem, Madrid, Spain

[4] Hosp Univ La Paz, Dept Biochem, Madrid, Spain

来源：

NEUROSCIENCE LETTERS | 1997年 / 238卷 / 03期

关键词：

Parkinson's disease; tau protein; cerebrospinal fluid;

D O I：

10.1016/S0304-3940(97)00858-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We measured total tau protein concentrations in the cerebrospinal fluid (CSF) of 26 non-demented Parkinson's disease (PD) patients and 25 matched controls. When compared with controls, PD patients had similar CSF tau protein concentrations. These values were not correlated with age, age at onset of PD, duration of PD, scores of the Unified PD Rating Scale (UPDRS), and the Hoehn and Yahr staging, and were not influenced significantly by antiparkinsonian drugs. Our results suggest that CSF tau protein levels are apparently unrelated to the risk of PD. (C) 1997 Elsevier Science Ireland Ltd.

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收藏

页码：139 / 141

页数：3

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