Synthesis of a Novel Biodegradable Polyurethane with Phosphatidylcholines

被引：13

作者：

Cao, Jun ^{[1
]}

Chen, Niancao ^{[1
]}

Chen, Yuanwei ^{[1
]}

Luo, Xianglin ^{[1
,2
]}

机构：

[1] Sichuan Univ, Coll Polymer Sci & Engn, Chengdu 610065, Peoples R China

[2] Sichuan Univ, State Key Lab Polymer Mat & Engn, Chengdu 610065, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2010年 / 11卷 / 04期

关键词：

polyurethanes; phosphatidylcholine; biodegradable; blood compatibility; polymer; surface; SCAFFOLDS;

D O I：

10.3390/ijms11041870

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A novel polyurethane was successfully synthesized by chain-extension of biodegradable poly (L-lactide) functionalized phosphatidylcholine (PC) with hexamethylene diisocyanate (HDI) as chain extender (PUR-PC). The molecular weights, glass transition temperature (Tg) increased significantly after the chain-extension. The hydrophilicity of PUR-PC was better than the one without PC, according to a water absorption test. Moreover, the number of adhesive platelets and anamorphic platelets on PUR-PC film were both less than those on PUR film. These preliminary results suggest that this novel polyurethane might be a better scaffold than traditional biodegradable polyurethanes for tissue engineering due to its better blood compatibility. Besides, this study also provides a new method to prepare PC-modified biodegradable polyurethanes.

引用

页码：1870 / 1877

页数：8

共 18 条

[1]

Polyurethane films seeded with embryonic stem cell-derived cardiomyocytes for use in cardiac tissue engineering applications [J].