Negative correlation of n-octanol/water partition coefficient and transport of some guanine derivatives through rat jejunum in vitro

被引：21

作者：

Kristl, A

Tukker, JJ

机构：

[1] Univ Ljubljana, Fac Pharm, Ljubljana 1000, Slovenia

[2] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Pharmaceut, NL-3508 TB Utrecht, Netherlands

来源：

PHARMACEUTICAL RESEARCH | 1998年 / 15卷 / 03期

关键词：

intestinal permeability; logP; acyclovir; deoxyacyclovir; Ussing and Sweetana-Grass cells;

D O I：

10.1023/A:1011901104421

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：499 / 501

页数：3

共 14 条

[1]

DARLY G, 1994, J INT MED RES S1, V22, pA33

[2] INVITRO MEASUREMENT OF GASTROINTESTINAL TISSUE PERMEABILITY USING A NEW DIFFUSION CELL [J].

GRASS, GM ;

SWEETANA, SA .

PHARMACEUTICAL RESEARCH, 1988, 5 (06) :372-376

[3] THE IONIZATION PROPERTIES OF ACYCLOVIR AND DEOXYACYCLOVIR [J].

KRISTL, A ;

MRHAR, A ;

KOZJEK, F .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1993, 99 (01) :79-82

[4] THERMODYNAMIC INVESTIGATION OF THE EFFECT OF OCTANOL WATER MUTUAL MISCIBILITY ON THE PARTITIONING AND SOLUBILITY OF SOME GUANINE DERIVATIVES [J].

KRISTL, A ;

VESNAVER, G .

JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS, 1995, 91 (06) :995-998

[5] MECHANISMS AND SITES OF MANNITOL PERMEABILITY OF SMALL AND LARGE-INTESTINE IN THE RAT [J].

KRUGLIAK, P ;

HOLLANDER, D ;

SCHLAEPFER, CC ;

NGUYEN, H ;

MA, TY .

DIGESTIVE DISEASES AND SCIENCES, 1994, 39 (04) :796-801

[6] CLINICAL PHARMACOKINETICS OF ACYCLOVIR [J].

LASKIN, OL .

CLINICAL PHARMACOKINETICS, 1983, 8 (03) :187-201

[7]

MAHONY WB, 1988, J BIOL CHEM, V263, P9285

[8]

MATTHES I, 1992, PHARMAZIE, V47, P787

[9] MECHANISM OF ACYCLOVIR UPTAKE IN RAT JEJUNUM [J].

MEADOWS, KC ;

DRESSMAN, JB .

PHARMACEUTICAL RESEARCH, 1990, 7 (03) :299-303

[10] BIOPHYSICAL MODELS AS AN APPROACH TO STUDY PASSIVE ABSORPTION IN DRUG DEVELOPMENT - 6-FLUOROQUINOLONES [J].

MERINO, V ;

FREIXAS, J ;

DELVALBERMEJO, M ;

GARRIGUES, TM ;

MORENO, J ;

PLADELFINA, JM .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1995, 84 (06) :777-782

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