Nanogels of Poly(acrylic acid): Uptake and Release Behavior with Fluorescent Oligothiophene-Labeled Bovine Serum Albumin

被引：21

作者：

Argentiere, Simona ^{[1
,2
]}

Blasi, Laura ^{[1
]}

Ciccarella, Giuseppe ^{[1
,3
]}

Barbarella, Giovanna ^{[4
]}

Cingolani, Roberto ^{[1
,3
]}

Gigli, Giuseppe ^{[1
,3
]}

机构：

[1] INFM, CNR, Natl Nanotechnol Labs, I-73100 Lecce, Italy

[2] Univ Salento, Ist Super Univ Formaz Interdisciplinare, Sez Nanosci, I-73100 Lecce, Italy

[3] Univ Salento, Dipartimento Ingn Innovaz, I-73100 Lecce, Italy

[4] ISOF, Area Ric, CNR, I-40129 Bologna, Italy

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2010年 / 116卷 / 05期

关键词：

stimuli-sensitive polymers; nanoparticles; emulsion polymerization; oligothiophene; uptake and release; DRUG-DELIVERY; EMULSION POLYMERIZATION; IONIC GELS; NANOPARTICLES; PH; HYDROGELS; PROTEINS; MICROGELS; BIONANOTECHNOLOGY; FORMULATIONS;

D O I：

10.1002/app.31691

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

Nanometer-sized poly(acrylic acid) (PAA) hydrogels were synthesized by emulsion polymerization of methyl acrylate and subsequent acidic hydrolysis. The nanohydrogel was characterized by spectroscopic methods (FTIR and H-1-NMR) and scanning probe techniques, and their pH-dependent swelling behavior was studied by dynamic light scattering. To determine the suitability of PAA nanogels as pH-sensitive carriers for biomedical applications, uptake and release of an oligothiophene fluorophore and its albumin conjugated from PAA nanogels were investigated as a function of pH by absorption and photoluminescence measurements. It was observed that uptake and release processes of both the oligothiophene and its conjugate could be controlled by changing the pH of the external solution. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 116: 2808-2815, 2010

引用

页码：2808 / 2815

页数：8

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