Possible involvement of T helper type 2 responses to Toll-like receptor ligands in IgG4-related sclerosing disease

被引：72

作者：

Akitake, Reiko ^{[1
]}

Watanabe, Tomohiro ^{[1
]}

Zaima, Chikage ^{[1
]}

Uza, Norimitsu ^{[1
]}

Ida, Hiroshi ^{[1
]}

Tada, Shinsuke ^{[1
]}

Nishida, Naoshi ^{[1
]}

Chiba, Tsutomu ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Sakyo Ku, Kyoto 6068507, Japan

来源：

GUT | 2010年 / 59卷 / 04期

关键词：

INFLAMMATORY-BOWEL-DISEASE; AUTOIMMUNE PANCREATITIS;

D O I：

10.1136/gut.2009.200972

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We report a case of immunoglobulin G4 (IgG4)-related sclerosing disease involving the pancreas, liver and salivary glands. Massive infiltration of IgG4-expressing plasma cells was seen in the liver and submandibular lymph nodes. Interestingly, accumulation of IgG4-expressing plasma cells was also seen in the colon and terminal ileum. Peripheral blood mononuclear cells (PBMCs) isolated from this patient exhibited enhanced production of IgG4 and interleukin-10 upon stimulation with Toll-like receptor (TLR) ligands as compared with those from a healthy control. In contrast, production of tumour necrosis factor alpha and interferon gamma by PBMCs from this patient was markedly reduced. Since colonic mucosa is always exposed to TLR ligands derived from commensal organisms, the results of immunological studies suggest that enhanced T helper type 2 responses to intestinal microflora may underlie the immunopathogenesis in this patient with IgG4-related sclerosing disease.

引用

页码：542 / 545

页数：4

共 15 条

[1] The use of immunoglobulin G4 immunostaining in diagnosing pancreatic and extrapancreatic involvement in autoimmune pancreatitis [J].

Deheragoda, Maesha G. ;

Church, Nicholas I. ;

Rodriguez-Justo, Manuel ;

Munson, Philippa ;

Sandanayake, Neomal ;

Seward, Edward W. ;

Miller, Keith ;

Novelly, Marco ;

Hatfield, Adrian R. W. ;

Pereira, Stephen P. ;

Webster, George J. M. .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2007, 5 (10) :1229-1234

[2] Current concepts - Autoimmune pancreatitis [J].

Finkelberg, Dnitry L. ;

Sahani, Dushyant ;

Deshpande, Vikrarn ;

Brugge, William R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (25) :2670-2676

[3]

Jeannin P, 1998, J IMMUNOL, V160, P3555

[4] Gastrointestinal findings in patients with autoimmune pancreatitis [J].

Kamisawa, T ;

Egawa, N ;

Nakajima, H ;

Tsuruta, K ;

Okamoto, A ;

Hayashi, Y ;

Funata, N .

ENDOSCOPY, 2005, 37 (11) :1127-1130

[5] Autoimmune pancreatitis: proposal of IgG4-related sclerosing disease [J].

Kamisawa, Terumi ;

Okamoto, Atsutake .

JOURNAL OF GASTROENTEROLOGY, 2006, 41 (07) :613-625

[6] A Novel Immunoglobulin-Immunoglobulin Interaction in Autoimmunity [J].

Kawa, Shigeyuki ;

Kitahara, Kei ;

Hamano, Hideaki ;

Ozaki, Yayoi ;

Arakura, Norikazu ;

Yoshizawa, Kaname ;

Umemura, Takeji ;

Ota, Masao ;

Mizoguchi, Sadaaki ;

Shimozuru, Yasunori ;

Bahram, Seiamak .

PLOS ONE, 2008, 3 (02)

[7] Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange [J].

Kolfschoten, Marijn van der Neut ;

Schuurman, Janine ;

Losen, Mario ;

Bleeker, Wim K. ;

Martinez-Martinez, Pilar ;

Vermeulen, Ellen ;

den Bleker, Tamara H. ;

Wiegman, Luus ;

Vink, Tom ;

Aarden, Lucien A. ;

De Baets, Marc H. ;

van De Winkel, Jan G. J. ;

Aalberse, Rob C. ;

Parren, Paul W. H. I. .

SCIENCE, 2007, 317 (5844) :1554-1557

[8] Circulating naive and CD4+CD25high regulatory T cells in patients with autoimmune pancreatitis [J].

Miyoshi, Hideaki ;

Uchida, Kazushige ;

Taniguchi, Takao ;

Yazumi, Shujiro ;

Matsushita, Mitsunobu ;

Takaoka, Makoto ;

Okazaki, Kazuichi .

PANCREAS, 2008, 36 (02) :133-140

[9] Autoimmune related pancreatitis [J].

Okazaki, K ;

Chiba, T .

GUT, 2002, 51 (01) :1-4

[10] Inflammatory Bowel Disease in the Setting of Autoimmune Pancreatitis [J].

Ravi, Karthik ;

Chari, Suresh T. ;

Vege, Santhi S. ;

Sandborn, William J. ;

Smyrk, Thomas C. ;

Loftus, Edward V., Jr. .

INFLAMMATORY BOWEL DISEASES, 2009, 15 (09) :1326-1330

← 1 2 →