Common gene variants, mortality and extreme longevity in humans

被引：39

作者：

Heijmans, BT

Westendorp, RGJ

Slagboom, PE ^{[1
]}

机构：

[1] TNO, Dept Vasc & Connect Tissue Res, Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Dept Gen Internal Med, Leiden, Netherlands

来源：

EXPERIMENTAL GERONTOLOGY | 2000年 / 35卷 / 6-7期

关键词：

longevity; mortality; ageing; genes; common gene variants; methylenetetrahydrofolate reductase; apolipoproteine E;

D O I：

10.1016/S0531-5565(00)00171-6

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Genetic factors influence variation in human life span. The fast technological advancements in genome research and the methodology for statistical analysis of complex traits provided new tools to unravel these genetic influences. Most of the genetic epidemiology and quantitative genetics is focused on the dissection of the genetic component of specific diseases rather than of human life span. Nevertheless, common variants of 22 genes have been tested for their contribution to mortality in the general population and extreme longevity in one or more studies. These studies provide indications as to the nature of biological pathways that might play a role in human ageing. Perhaps even more important at this time is the fact that they give valuable insights in the strengths and weaknesses of current strategies to identify gene variants affecting human life span and point at more powerful approaches. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：865 / 877

页数：13

共 77 条

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