Cytotoxic isoquinoline alkaloids from the aerial parts of Corydalis incisa

被引：44

作者：

Choi, Sang Un

Baek, Nam-In

Kim, Sung-Hoon

Yang, Jae Heon

Eun, Jae Soon

Shin, Tae Yong

Lim, Jong Pil

Lee, Jae Hyeok

Jeon, Hoon

Yun, Mi-Young

Leem, Kang-Hyun

Park, Hee Wook

Kim, Dae Keun ^{[1
]}

机构：

[1] Woosuk Univ, Coll Pharm, Samrye 565701, South Korea

[2] Korea Res Inst Chem Technol, Taejon 305600, South Korea

[3] Kyung Hee Univ, Grad Sch Biotechnol & Plant Metab, Res Ctr, Suwon 449701, South Korea

[4] Kyung Hee Univ, Lab Angiogenesis & Chemoprevent, Dept Oriental Pathol, Coll Oriental Med, Seoul 131701, South Korea

[5] Nambu Univ, Dept Oriental Pharmaceut Dev, Kwangju 506706, South Korea

[6] Semyung Univ, Coll Oriental Med, Chechon 390711, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2007年 / 30卷 / 02期

关键词：

Corydalis incisa; Papaveraceae; isoquinoline alkaloids;

D O I：

10.1007/BF02977687

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three known isoquinoline alkaloids were isolated from the chloroform-soluble fraction of the methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) through repeated column chromatography. Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and 6-oxocorynoline (3) using spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2 and HCT15 tumor cells.

引用

页码：151 / 154

页数：4

共 12 条

[1] MORPHINANDIENONE ALKALOIDS FROM CORYDALIS-INCISA [J].