In vivo radiotracers for vesicular neurotransmitter transporters

被引：42

作者：

Kilbourn, MR

机构：

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1997年 / 24卷 / 07期

关键词：

vesicle; transporter; tetrabenazine; monoamine; tomography; emission computed;

D O I：

10.1016/S0969-8051(97)00101-7

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The vesicular monoamine transporter is a specific presynaptic protein involved in the transport of monoamines from the cytosol to storage vesicles of monoaminergic nerve terminals. Recently, radioligands for this transporter have been developed and utilized for in vivo positron emission tomographic (PET) imaging of monoaminergic nerve terminals in the human brain. In this review, the characteristics of vesicular transport and storage that provided the impetus for development of these radioligands are presented and discussed. (C) 1997 Elsevier Science Inc.

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页码：615 / 619

页数：5

相关论文

共 44 条

[1] Aromatic L-amino acid decarboxylase: A neglected and misunderstood enzyme [J].

Berry, MD ;

Juorio, AV ;

Li, XM ;

Boulton, AA .

NEUROCHEMICAL RESEARCH, 1996, 21 (09) :1075-1087

[2] MODIFICATION OF VESICULAR DOPAMINE AND NOREPINEPHRINE BY MONOAMINE-OXIDASE INHIBITORS [J].

BUU, NT .

BIOCHEMICAL PHARMACOLOGY, 1989, 38 (10) :1685-1692

[3]

CARROLL FI, 1995, MED RES REV, V15, P419

[4] NEURAL DEGENERATION AND THE TRANSPORT OF NEUROTRANSMITTERS [J].

EDWARDS, RH .

ANNALS OF NEUROLOGY, 1993, 34 (05) :638-645

[5]

ERICKSON JD, 1994, J BIOL CHEM, V269, P21929

[6]

FLOOR E, 1995, J NEUROCHEM, V64, P689

[7] Presynaptic monoaminergic vesicles in Parkinson's disease and normal aging [J].

Frey, KA ;

Koeppe, RA ;

Kilbourn, MR ;

VanderBorght, TM ;

Albin, RL ;

Gilman, S ;

Kuhl, DE .

ANNALS OF NEUROLOGY, 1996, 40 (06) :873-884

[8] Decreased striatal monoaminergic terminals in olivopontocerebellar atrophy and multiple system atrophy demonstrated with positron emission tomography [J].

Gilman, S ;

Frey, KA ;

Koeppe, RA ;

Junck, L ;

Little, R ;

VanderBorght, TM ;

Lohman, M ;

Martorello, S ;

Lee, LC ;

Jewett, DM ;

Kilbourn, MR .

ANNALS OF NEUROLOGY, 1996, 40 (06) :885-892

[9] RADIOLIGANDS OF THE VESICULAR MONOAMINE TRANSPORTER AND THEIR USE AS MARKERS OF MONOAMINE STORAGE-VESICLES [J].

HENRY, JP ;

SCHERMAN, D .

BIOCHEMICAL PHARMACOLOGY, 1989, 38 (15) :2395-2404

[10]

JEWETT DM, 1997, APPL RADIAT ISOTOPES, V24, P197

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