Pd(II)-Catalyzed Olefination of sp3 C-H Bonds

被引：326

作者：

Wasa, Masayuki ^{[1
]}

Engle, Keary M. ^{[1
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 11期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

CROSS-COUPLING REACTIONS; FUNCTIONALIZATION; INDOLES; ACTIVATION; VINYLATION; ANILIDES; ALKENES; HALIDES;

D O I：

10.1021/ja1010866

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first Pd(II)-catalyzed sp(3) C-H olefination reaction has been developed using N-arylamide directing groups. Following olefination, the resulting intermediates were found to undergo rapid 1,4-addition to give the corresponding gamma-lactams. Notably, this method was effective with substrates containing a-hydrogen atoms and could be applied to effect methylene C-H olefination of cyclopropane Substrates.

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页码：3680 / +

页数：4

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