White-matter integrity predicts stroop performance in patients with geriatric depression

被引:153
作者
Murphy, Christopher F.
Gunning-Dixon, Faith M.
Hoptman, Matthew J.
Lim, Kelvin O.
Ardekani, Babak
Shields, Jessica K.
Hrabe, Jan
Kanellopoulos, Dora
Shanmugham, Binclu R.
Alexopoulos, George S.
机构
[1] Cornell Univ, Weill Med Coll, Neill Cornell Inst Geriatr Psychiat, White Plains, NY 10605 USA
[2] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA
[3] NYU, Sch Med, Dept Psychiat, New York, NY USA
[4] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA
关键词
depression; DTI; executive function; geriatric; MRI; stroop;
D O I
10.1016/j.biopsych.2006.07.028
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Background: This study tested the hypothesis that microstructural white matter abnormalities in frontostriatal-limbic tracts are associated with poor response inhibition on the Stroop task in depressed elders. Method: Fifty-one elders with major depression participated in a 12-week escitalopram trial. Diffusion tensor imaging was used to determine fractional anisotropy (FA) in white matter regions. Executive function (response inhibition) was assessed with the Stroop task. Voxelvvise correlational analysis was used to examine the relationship between Stroop performance and fractional anisotropy. Results: Significant associations between FA and Stroop color word interference were evident in multiple frontostriatal-limbic regions, including white matter lateral to the anterior and posterior cingulate cortex and white matter in prefrontal, insular, and parahippocampal regions. Conclusions: These findings suggest that microstructural white matter abnormalities of frontostriatal-limbic networks are associated with executive dysfunction of late-life depression. This observation provides the rationale for examination of specific frontostriatal-limbic pathways in the pathophysiology of geriatric depression.
引用
收藏
页码:1007 / 1010
页数:4
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