Lignans with inhibitory activity against NFAT transcription from Schisandra chinensis

被引：29

作者：

Lee, IS

Lee, HK

Dat, NT

Lee, MS

Kim, LW

Na, DS

Kim, YH ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Immunomodulator Res Lab, Taejon, South Korea

[3] Pai Chai Univ, Div Life Sci, Biomed RRC, Taejon, South Korea

[4] Univ Ulsan, Coll Med, Seoul 138736, South Korea

来源：

PLANTA MEDICA | 2003年 / 69卷 / 01期

关键词：

D O I：

10.1055/s-2003-37024

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Seven lignans from Schisandra chinensis were investigated for their inhibitory activity on NFAT transcription. Both gomisin N (IC50:1.33 +/- 0.05 muM) and schisandrol A (IC50:1.34 +/- 0.05 muM) showed higher-activity than gomisin E (IC50:4.73 +/- 0.09 muM), schisandrin A (IC50:7.23 +/- 0.21 muM), schisandrin C (IC50:7.54 +/- 0.22 muM), benzoylisogomisin O (IC50:11.06 +/- 1.02 muM) and schisandrol B (IC50:16.37 +/- 1.00 muM).

引用

页码：63 / 64

页数：2

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