Platelet-Rich Plasma for the Management of Hip and Knee Osteoarthritis

被引:220
作者
Bennell, Kim L. [1 ]
Hunter, David J. [2 ,3 ]
Paterson, Kade L. [1 ]
机构
[1] Univ Melbourne, Sch Hlth Sci, Dept Physiotherapy, Ctr Hlth Exercise & Sports Med, Parkville, Vic 3010, Australia
[2] Univ Sydney, Inst Bone & Joint Res, Kolling Inst, Royal North Shore Hosp, Sydney, NSW, Australia
[3] Univ Sydney, Rheumatol Dept, Royal North Shore Hosp, Sydney, NSW, Australia
基金
英国医学研究理事会;
关键词
Platelet-rich plasma; Osteoarthritis; Knee pain; Intra-articular therapy; RANDOMIZED CONTROLLED-TRIAL; FACTORS PRGF-ENDORET; HYALURONIC-ACID; GROWTH-FACTORS; INTRAARTICULAR INJECTIONS; ULTRASOUND GUIDANCE; ARTICULAR-CARTILAGE; CLINICAL-TRIAL; DOUBLE-BLIND; OUTCOMES;
D O I
10.1007/s11926-017-0652-x
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Purpose of Review Knee and hip osteoarthritis (OA) are major public health problems worldwide causing pain, disability and impaired quality of life. This narrative paper discusses platelet-rich plasma (PRP) as a treatment for hip and knee OA, with a focus on evidence from randomised controlled trials (RCTs). Recent Findings Since the first RCTof PRP in 2012, there has been 15 RCTs in knee OA and three in hip OA, mostly comparing PRP to another intra-articular injection therapy, hyaluronic acid. All studies are of low to moderate methodological quality and use variable PRP protocols. In general, results showed that PRP is a safe treatment with potential to provide symptomatic benefit for OA at least in the short term (up to 12 months). Younger patients with less severe disease may be more responsive. There are no RCTs investigating the effects of PRP on OA structural changes. Summary No definitive conclusions can be made about the effects of PRP in OA given methodological concerns and considerable heterogeneity between studies. Further high-quality research is needed to establish the clinical and cost-effectiveness of PRP, the patients most likely to benefit and the optimal PRP protocol.
引用
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页数:10
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