High-efficiency and minimum-waste continuous kinetic resolution of racemic alcohols by using lipase in supercritical carbon dioxide

被引：38

作者：

Matsuda, T ^{[1
]}

Watanabe, K

Harada, T

Nakamura, K

Arita, Y

Misumi, Y

Ichikawa, S

Ikariya, T

机构：

[1] Ryukoku Univ, Dept Chem Mat, Shiga 5202194, Japan

[2] Kyoto Univ, Inst Chem Res, Kyoto 6110011, Japan

[3] Tokyo Inst Technol, JCII, Joint Res Ctr Supercrit Fluids, Meguro Ku, Tokyo 1528552, Japan

[4] Tokyo Inst Technol, Grad Sch Sci & Engn, Meguro Ku, Tokyo 1528552, Japan

[5] Tokyo Inst Technol, Frontier Collaborat Res Ctr, Meguro Ku, Tokyo 1528552, Japan

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 20期

关键词：

D O I：

10.1039/b406882c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel continuous-flow scCO(2) process for kinetic resolution of racemic alcohols can be performed with an immobilized lipase to lead to a quantitative mixture of the corresponding optically active acetates with up to 99% ee and unreacted alcohols with up to 99% ee, in which the productivity of the optically active compounds was improved by over 400 times compared to the corresponding batch reaction using scCO(2).

引用

页码：2286 / 2287

页数：2

共 30 条

[1]

[Anonymous], 1999, CHEM SYNTHESIS USING

[2] Multiphase catalysis using water-soluble metal complexes in supercritical carbon dioxide [J].