Pathway of membrane fusion with two tension-dependent energy barriers

被引：152

作者：

Grafmueller, Andrea ^{[1
]}

Shillcock, Julian ^{[1
]}

Lipowsky, Reinhard ^{[1
]}

机构：

[1] Max Planck Inst Colloids & Interfaces, D-14424 Potsdam, Germany

来源：

PHYSICAL REVIEW LETTERS | 2007年 / 98卷 / 21期

关键词：

D O I：

10.1103/PhysRevLett.98.218101

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Fusion of bilayer membranes is studied via dissipative particle dynamics (DPD) simulations. A new set of DPD parameters is introduced which leads to an energy barrier for flips of lipid molecules between adhering membranes. A large number of fusion events is monitored for a vesicle in contact with a planar membrane. Several time scales of the fusion process are found to depend exponentially on the membrane tension. This implies an energy barrier of about 10k(B)T for intermembrane flips and a second size-dependent barrier for the nucleation of a small hemifused membrane patch.

引用

页数：4

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