Dementia and ageing

被引:6
作者
Good, CD [1 ]
机构
[1] UCL, Neurol Inst, Wellcome Dept Cognit Neurol, London WC1N 3BG, England
关键词
D O I
10.1093/bmb/65.1.159
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Sophisticated imaging techniques are required to characterise the complex dynamic neuro-anatomical changes that occur over time in health and disease. With the advent of potential therapies for the treatment of degenerative demential, imaging strategies need to enable early diagnosis and facilitate monitoring of disease progression in treatment trials. This chapter highlights some of the innovative structural and functional imaging techniques that have impacted on the clinical management of Alzheimer's disease.
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页码:159 / +
页数:13
相关论文
共 39 条
[1]   Voxel-based morphometry - The methods [J].
Ashburner, J ;
Friston, KJ .
NEUROIMAGE, 2000, 11 (06) :805-821
[2]   In vivo mapping of gray matter loss with voxel-based morphometry in mild Alzheimer's disease [J].
Baron, JC ;
Chételat, G ;
Desgranges, B ;
Perchey, G ;
Landeau, B ;
de la Sayette, V ;
Eustache, F .
NEUROIMAGE, 2001, 14 (02) :298-309
[3]   HM-PAO (CERETEC) SPECT brain scanning in the diagnosis of Alzheimer's disease [J].
Bergman, H ;
Chertkow, H ;
Wolfson, C ;
Stern, J ;
Rush, C ;
Whitehead, V ;
Dixon, R .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1997, 45 (01) :15-20
[4]   MULTIMODAL IMAGING IN ALZHEIMERS-DISEASE - THE RELATIONSHIP BETWEEN MRI, SPECT, COGNITIVE AND PATHOLOGICAL-CHANGES [J].
BESSON, JAO ;
CRAWFORD, JR ;
PARKER, DM ;
EBMEIER, KP ;
BEST, PV ;
GEMMELL, HG ;
SHARP, PF ;
SMITH, FW .
BRITISH JOURNAL OF PSYCHIATRY, 1990, 157 :216-220
[5]  
Bosma GPT, 2000, ARTHRITIS RHEUM-US, V43, P2428, DOI 10.1002/1529-0131(200011)43:11<2428::AID-ANR9>3.0.CO
[6]  
2-H
[7]   Quantification of tissue damage in AD using diffusion tensor and magnetization transfer MRI [J].
Bozzali, M ;
Franceschi, M ;
Falini, A ;
Pontesilli, S ;
Cercignani, M ;
Magnani, G ;
Scotti, G ;
Comi, G ;
Filippi, M .
NEUROLOGY, 2001, 57 (06) :1135-1137
[8]  
Bozzao A, 2001, AM J NEURORADIOL, V22, P1030
[9]   Specificity of brain activation patterns in people at genetic risk for Alzheimer disease [J].
Burggren, AC ;
Small, GW ;
Sabb, FW ;
Bookheimer, SY .
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2002, 10 (01) :44-51
[10]   In-vivo measurement of activated microglia in dementia [J].
Cagnin, A ;
Brooks, DJ ;
Kennedy, AM ;
Gunn, RN ;
Myers, R ;
Turkheimer, FE ;
Jones, T ;
Banati, RB .
LANCET, 2001, 358 (9280) :461-467