Paradoxes of the EphB4 receptor in cancer

被引：116

作者：

Noren, Nicole K.

Pasquale, Elena B.

机构：

[1] Burke Med Res Inst, La Jolla, CA 92037 USA

[2] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA

来源：

CANCER RESEARCH | 2007年 / 67卷 / 09期

关键词：

D O I：

10.1158/0008-5472.CAN-07-0525

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent findings have started to uncover the intriguing roles of the Eph family of receptor tyrosine kinases in normal epithelial cells and during oncogenic transformation. This review focuses on EphB4, an Eph receptor that has both tumor-suppressing and tumor-promoting activities in breast cancer. Understanding the multifaceted role of EphB4 in tumorigenesis may allow the development of new anticancer therapies.

引用

页码：3994 / 3997

页数：4

共 29 条

[1] Eph and ephrin signaling in mammary gland morphogenesis and cancer [J].

Andres, AC ;

Ziemiecki, A .

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2003, 8 (04) :475-485

[2] Eph/Ephrin signaling regulates the mesenchymal-to-epithelial transition of the paraxial mesoderm during somite morphogenesis [J].

Barrios, A ;

Poole, RJ ;

Durbin, L ;

Brennan, C ;

Holder, N ;

Wilson, SW .

CURRENT BIOLOGY, 2003, 13 (18) :1571-1582

[3]

Berclaz G, 2002, ONCOL REP, V9, P985

[4] Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold [J].

Chodniewicz, D ;

Klemke, RL .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2004, 1692 (2-3) :63-76

[5] EphB/EphrinB receptors and Wnt signaling in colorectal cancer [J].

Clevers, H ;

Batlle, E .

CANCER RESEARCH, 2006, 66 (01) :2-5

[6] EPHB4 and survival of colorectal cancer patients [J].

Davalos, Veronica ;

Dopeso, Higinio ;

Castano, Julio ;

Wilson, Andrew J. ;

Vilardell, Felip ;

Romero-Gimenez, Jordi ;

Espin, Eloy ;

Armengol, Manel ;

Capella, Gabriel ;

Mariadason, John M. ;

Aaltonen, Lauri A. ;

Schwartz, Simo, Jr. ;

Arango, Diego .

CANCER RESEARCH, 2006, 66 (18) :8943-8948

[7] EphB4 controls blood vascular morphogenesis during postnatal angiogenesis [J].

Erber, R ;

Eichelsbacher, U ;

Powajbo, V ;

Korn, T ;

Djonov, V ;

Lin, JH ;

Hammes, HP ;

Grobholz, R ;

Ullrich, A ;

Vajkoczy, P .

EMBO JOURNAL, 2006, 25 (03) :628-641

[8] Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin [J].

Guo, Hong ;

Miao, Hui ;

Gerber, Lizabeth ;

Singh, Jarnail ;

Denning, Mitchell F. ;

Gilliam, Anita C. ;

Wang, Bingcheng .

CANCER RESEARCH, 2006, 66 (14) :7050-7058

[9] Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer [J].

Huusko, P ;

Ponciano-Jackson, D ;

Wolf, M ;

Kiefer, JA ;

Azorsa, DO ;

Tuzmen, S ;

Weaver, D ;

Robbins, C ;

Moses, T ;

Allinen, M ;

Hautaniemi, S ;

Chen, YD ;

Elkahloun, A ;

Basik, M ;

Bova, GS ;

Bubendorf, L ;

Lugli, A ;

Sauter, G ;

Schleutker, J ;

Ozcelik, H ;

Elowe, S ;

Pawson, T ;

Trent, JM ;

Carpten, JD ;

Kallioniemi, OP ;

Mousses, S .

NATURE GENETICS, 2004, 36 (09) :979-983

[10]

Hyytinen ER, 1999, GENE CHROMOSOME CANC, V25, P108, DOI 10.1002/(SICI)1098-2264(199906)25:2<108::AID-GCC6>3.3.CO

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