Synthesis of 4-acetylcolchicine

被引：4

作者：

Kouroupis, P

Linden, A

Hansen, HJ

机构：

[1] Organ.-chemisches Inst. der Univ., CH-8057 Zürich

来源：

HELVETICA CHIMICA ACTA | 1996年 / 79卷 / 01期

关键词：

D O I：

10.1002/hlca.19960790120

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of 4-acetylcolchicine (1) by Swern dehydrogenation of the corresponding mixture of 4-[(R)-1-hydroxyethyl]- and 4-[(S)-1-hydroxyethyl]colchicine (3a and 3b, respectively) is described (cf. Scheme). The X-ray analysis of 1 (cf. Fig.), crystallized from MeOH, showed the presence of MeOH in the crystals.

引用

页码：203 / 207

页数：5

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