NMDA receptors are critical for unleashing consolidated auditory fear memories

被引：259

作者：

Ben Mamou, Cyrinne ^{[1
]}

Gamache, Karine ^{[1
]}

Nader, Karim ^{[1
]}

机构：

[1] McGill Univ, Dept Psychol, Montreal, PQ H3A 1B1, Canada

来源：

NATURE NEUROSCIENCE | 2006年 / 9卷 / 10期

基金：

加拿大健康研究院; 加拿大创新基金会; 加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1038/nn1778

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Memories are dynamic and can change when recalled. The process that returns memories to a labile state during remembering is unclear. We found that the presence of NMDA, but not AMPA, receptor antagonists in the amygdala prior to recall prevented the consolidated fear memory from returning to a labile state. These findings suggest that NMDA receptors in the amygdala are critical for transforming a memory from a fixed to a labile state.

引用

页码：1237 / 1239

页数：3

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