Accuracy of the Papanicolaou test in screening for and follow-up of cervical cytologic abnormalities: A systematic review

被引:784
作者
Nanda, K
McCrory, DC
Myers, ER
Bastian, LA
Hasselblad, V
Hickey, JD
Matchar, DB
机构
[1] Duke Univ, Med Ctr, Ctr Clin Hlth Policy Res, Durham, NC 27705 USA
[2] Durham Vet Affairs Med Ctr, Hlth Serv Res & Dev 152, Durham, NC 27705 USA
关键词
D O I
10.7326/0003-4819-132-10-200005160-00009
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose: To evaluate the accuracy of conventional and new methods of Papanicolaou (Pap) testing when used to detect cervical cancer and its precursors. Data Sources: Systematic search of English-language literature through October 1999 using MEDLINE, EMBASE, other computerized databases, and hand searching. Study Selection: Ail studies that compared Pap testing (conventional methods, computer screening or rescreening, or monolayer cytology) with a concurrent reference standard (histologic examination, colposcopy, or cytology). Data Extraction: Two reviewers independently reviewed selection criteria and completed 2 x 2 tables for each study. Data Synthesis: 94 studies of the conventional Pap test and three studies of monolayer cytology met inclusion criteria. No studies of computerized screening were included. Data were organized by cytologic and histologic thresholds used to define disease. For conventional Pap tests, estimates of sensitivity and specificity varied greatly in individual studies. Methodologic quality and frequency of histologic abnormalities also varied greatly between studies. In the 12 studies with the least biased estimates, sensitivity ranged from 30% to 87% and specificity ranged from 86% to 100%. Conclusions: Insufficient high-quality data exist to estimate test operating characteristics of new cytologic methods for cervical screening. Future studies of these technologies should apply adequate reference standards. Most studies of the conventional Pap test are severely biased: The best estimates suggest that it is only moderately accurate and does not achieve concurrently high sensitivity and specificity. Cost-effectiveness models of cervical cancer screening should use more conservative estimates of Pap test sensitivity.
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页码:810 / 819
页数:10
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