Replication timing and metazoan evolution

被引：14

作者：

Gilbert, DM ^{[1
]}

机构：

[1] SUNY Upstate Med Ctr, Dept Biochem & Mol Biol, Syracuse, NY 13210 USA

来源：

NATURE GENETICS | 2002年 / 32卷 / 03期

关键词：

D O I：

10.1038/ng1102-336

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The long-presumed relationship between transcriptional activity of genes and their replication early in S-phase was challenged when a whole-genome analysis of replication timing in budding yeast found no such relationship. A new study reports the first genome-wide comparison of replication timing and gene expression in a multicellular organism, revealing a strong correlation between the two. This difference may reflect levels of nuclear organization that are important in the context of tissue-specific gene regulation.

引用

页码：336 / 337

页数：3

共 15 条

[1] Heterogeneity of eukaryotic replicons, replicon clusters, and replication foci [J].

Berezney, R ;

Dubey, DD ;

Huberman, JA .

CHROMOSOMA, 2000, 108 (08) :471-484

[2]

BICKMORE WA, 1995, J CELL SCI, V108, P2801

[3] Nuclear architecture - Visualizing chromatin dynamics in interphase nuclei [J].

Gasser, SM .

SCIENCE, 2002, 296 (5572) :1412-1416

[4] Replication timing and transcriptional control: beyond cause and effect [J].

Gilbert, DM .

CURRENT OPINION IN CELL BIOLOGY, 2002, 14 (03) :377-383

[5]

HUTCHISON CJ, IN PRESS NATURE REV

[6] To fire or not to fire:: origin activation in Saccharomyces cerevisiae ribosomal DNA [J].

Ivessa, AS ;

Zakian, VA .

GENES & DEVELOPMENT, 2002, 16 (19) :2459-2464

[7] Translating the histone code [J].

Jenuwein, T ;

Allis, CD .

SCIENCE, 2001, 293 (5532) :1074-1080

[8] Regulation of replication timing in fission yeast [J].

Kim, SM ;

Huberman, JA .

EMBO JOURNAL, 2001, 20 (21) :6115-6126

[9] Chromatin and transcription: where do we go from here? Commentary [J].

Kornberg, RD ;

Lorch, Y .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2002, 12 (02) :249-251

[10] A core nucleosome surface crucial for transcriptional silencing [J].

Park, JH ;

Cosgrove, MS ;

Youngman, E ;

Wolberger, C ;

Boeke, JD .

NATURE GENETICS, 2002, 32 (02) :273-279

← 1 2 →