How do I fatten thee? Let me count the ways...

被引：15

作者：

Coleman, Rosalind A. ^{[1
]}

机构：

[1] Univ N Carolina, Dept Nutr & Pediat, Chapel Hill, NC 27599 USA

来源：

CELL METABOLISM | 2007年 / 5卷 / 02期

关键词：

D O I：

10.1016/j.cmet.2007.01.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Glycerol-3-phosphate acyltransferase (GPAT) initiates the synthesis of triacylglycerol and phospholipids and, in the process, regulates the formation of several lipid metabolites known to be intracellular signaling molecules. The recent identification of a new GPAT isoform (Cao et al., 2006) suggests a role for GPAT isoforms in nutrient-mediated signaling.

引用

页码：87 / 89

页数：3

共 11 条

[1] Agpat6 -: a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium [J].

Beigneux, AP ;

Vergnes, L ;

Qiao, X ;

Quatela, S ;

Davis, R ;

Watkins, SM ;

Coleman, RA ;

Walzem, RL ;

Philips, M ;

Reue, K ;

Young, SG .

JOURNAL OF LIPID RESEARCH, 2006, 47 (04) :734-744

[2] Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis [J].

Cao, Jingsong ;

Li, Jian-Liang ;

Li, Dongmei ;

Tobin, James F. ;

Gimeno, Ruth E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (52) :19695-19700

[3] Enzymes of triacylglycerol synthesis and their regulation [J].

Coleman, RA ;

Lee, DP .

PROGRESS IN LIPID RESEARCH, 2004, 43 (02) :134-176

[4]

GONZALEZBARO MR, 2006, AM J PHYSIOL-GASTR L, DOI DOI 10.1152/AJPGI.0053.02006

[5] Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs [J].

Hammond, LE ;

Neschen, S ;

Romanelli, AJ ;

Cline, GW ;

Ilkayeva, OR ;

Shulman, GI ;

Muoio, DM ;

Coleman, RA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (27) :25629-25636

[6] Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition [J].

Hammond, LE ;

Gallagher, PA ;

Wang, SL ;

Hiller, S ;

Kluckman, KD ;

Posey-Marcos, EL ;

Maeda, N ;

Coleman, RA .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (23) :8204-8214

[7] METABOLISM OF LIPIDES [J].

KENNEDY, EP .

ANNUAL REVIEW OF BIOCHEMISTRY, 1957, 26 :119-148

[8] Identification of a new glycerol-3-phosphate acyltransferase isoenzyme, mtGPAT2, in mitochondria* [J].

Lewin, TM ;

Schwerbrock, NMJ ;

Lee, DP ;

Coleman, RA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (14) :13488-13495

[9] Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice [J].

Neschen, S ;

Morino, K ;

Hammond, LE ;

Zhang, DY ;

Liu, ZX ;

Romanelli, AJ ;

Cline, GW ;

Pongratz, RL ;

Zhang, XM ;

Choi, CS ;

Coleman, RA ;

Shulman, GI .

CELL METABOLISM, 2005, 2 (01) :55-65

[10] Etiology of insulin resistance [J].

Petersen, KF ;

Shulman, GI .

AMERICAN JOURNAL OF MEDICINE, 2006, 119 (05) :10S-16S

← 1 2 →