Histological Changes in Chinese Chronic Hepatitis B Patients with ALT Lower Than Two Times Upper Limits of Normal

被引：55

作者：

Chen, En-Qiang ^{[1
]}

Huang, Fei-Jun ^{[2
]}

He, Ling-Li ^{[1
]}

Bai, Lang ^{[1
]}

Wang, Li-Chun ^{[1
]}

Zhou, Tao-You ^{[1
]}

Lei, Xue-Zhong ^{[1
]}

Liu, Cong ^{[1
]}

Tang, Hong ^{[1
]}

机构：

[1] Sichuan Univ, W China Hosp, Natl Key Lab Biotherapy, Ctr Infect Dis,Div Mol Biol Infect Dis, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, Coll Basic Med & Forens Med, Dept Forens Pathol, Chengdu 610041, Sichuan, Peoples R China

来源：

DIGESTIVE DISEASES AND SCIENCES | 2010年 / 55卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Hepatitis B virus; Liver biopsy; Inflammation; Fibrosis; ALT; TREATMENT ALGORITHM; VIRAL-HEPATITIS; VIRUS INFECTION; HIGH PREVALENCE; DISEASE; RISK; MANAGEMENT; ANTIGEN;

D O I：

10.1007/s10620-009-0724-5

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The role of ALT as a predictor of liver injury has been questioned. The aim of this study is to use liver biopsy to assess the degree of liver injury in patients with chronic hepatitis B(CHB) whose ALT < 2 x upper limit of normal (ULN). A total of 49.2% of patients in this study had significant inflammation (grade >= 2) and 36.4% had significant fibrosis (stage >= 2). The frequency of serious inflammation and fibrosis was similar in patients with different ALT levels. The level of serum HBV DNA was not significantly associated with the extent of inflammation and fibrosis. Advanced age was a significant independent predictor of histological damage and the presence of more significant inflammation and fibrosis. We conclude that many CHB patients with ALT < 2 x ULN have significant liver inflammation or fibrosis and that liver biopsy is necessary to assess liver damage and should be used to assess the need for anti-viral therapy.

引用

页码：432 / 437

页数：6

共 26 条

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